Amyloidosis is a heterogeneous group of diseases with a common outcome: deposition of insoluble protein in the visceral organs and tissues. Primary amyloidosis is a consequence of different plasma cell disorders, and it is the most common form of amyloidosis in the United States with an estimated 2,000 new cases annually. Other forms of amyloidosis include chronic inflammatory processes, famili...

Recent studies have demonstrated a reduction in body fat in growing animals fed conjugated linoleic acid (CLA). Two experiments were conducted to extend these observations to obese rats so that the mechanism of the actions of CLA might be more easily elucidated. In experiment 1, male lean and obese Zucker rats were fed diets containing either 0 or 0.5% CLA for 5 wk. There was no effect of diet ...

Jongman J, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-219775 DESCRIPTION A 65-year-old patient with no medical history of notice was referred to our cardiology outpatient clinic for the evaluation of exertional dyspnoea. After a thorough work-up, the suspicion of an amyloid cardiomyopathy was raised by the cardiac magnetic resonance (CMR) findings (figure 1A–C), but laboratory tests, abdomi...

Estrogen, via estrogen receptor alpha (ERα), exerts several beneficial effects on metabolism and energy homeostasis by controlling size, enzymatic activity and hormonal content of adipose tissue. The actions of estrogen on sympathetic ganglia, which are key players in the browning process, are less well known. In the present study we show that ERβ influences browning of subcutaneous adipose tis...

Study of Coincidence Hoffa’s Fat Pad Associated Injuries in Knee Traumas Magnetic Resonance Imaging

BACKGROUND The "obesity paradox" is defined as an inverse association of good health, survival and obesity. Usually in healthy persons the more obese you are the more metabolic complications you have; however, thin patients with chronic obstructive pulmonary disease (COPD) have more cardiovascular complications and a higher mortality rate. OBJECTIVES To explore whether atherosclerosis and per...