PURPOSE In epilepsy, many studies were focus on apoE gene polymorphism and found APOE epsilon4 to be associated with earlier onset of temporal lobe epilepsy. There is not any study about apoE in cerebrospinal fluid (CSF) of epileptic patients, so we detect the CSF-apoE and determine whether it is changed after seizure. METHODS A total of 60 epileptic patients and 28 subjects with no evidence ...

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The generalized differential quadrature (GDQ) method is used to obtain the computational results of two-layer cross-ply laminated shell under rapid uniform heat induced vibration. In the thermally insulated vibration analyses of a laminated shell, the sudden uniform heat input over its lower surface only and temperature load is linear of axial coordinate. The GDQ method provides a method for ca...

Multi-functional neural probes integrated with various stimulation modalities are becoming essential tools in neuroscience to study the brain more effectively. In this paper, we present a new multi-functional neural probe that allows chemical stimulation through drug delivery and simultaneous recording of individual neuron signals through a microelectrode array. By embedding microchannels in si...

introduction: seizure is the most common pediatric neurology problem that occurs in 10% of children. the purpose of this study was to determine the recurrence rate of seizures after one year and its relationship with paraclinical findings of the first attack. methods : in a historical cohort analytic study , 131 children with first seizure admitted to shaheed sadoughi hospital between march 200...

The invertible, compact and Fredholm multiplication operators on generalized Lorentz-Zygmund (GLZ) spaces Lp,q;α, 1 < p ≤ ∞, 1 ≤ q ≤ ∞, α in the Euclidean space R, are characterized in this paper.

In high-dose intake of phenytoin, which is used frequently to treat epilepsy, nystagmus, diplopia, nausea-vomiting, lethargy, confusion, seizure, and coma can be observed. In recent studies on phenytoin intoxication, in which seizure and coma were observed in drug levels greater than 50 ug/mL. The serum phenytoin level of a patient, who consumed approximately 100 pcs of 100 mg phenytoin tablets...

Voltage-gated sodium channel (VGSC) mutations cause severe epilepsies marked by intermittent, pathological hypersynchronous brain states. Here we present two mechanisms that help to explain how mutations in one VGSC gene, Scn8a, contribute to two distinct seizure phenotypes: (1) hypoexcitation of cortical circuits leading to convulsive seizure resistance, and (2) hyperexcitation of thalamocorti...