Large cell acanthoma (LCA) is a benign epidermal tumor that presents with pigmented hyperkeratotic patch well-demarcated boundaries in sun-exposed areas. Since various tumors present overlapping clinical and histopathological features, additional methods to differentiate them would be of great significance. Although there are numerous data on the dermoscopic findings other comparable tumors, la...

Sir, Cilazapril is a new angiotensin converting enzyme inhibitor (ACEI) which, like other ACEIs, is a non-thiol molecule, containing an active amide group. Since the early 1990s an increasing number of case reports have been published pointing to the role of this family of drugs in inducing or triggering pemphigus (1). In 1992, the ACEI Enalapril was found to be the most powerful acantholytic d...

Darier disease (DD) is a rare dominantly inherited genodermatosis characterized by loss of intercellular adhesion (acantholysis) and abnormal keratinization. DD is often difficult to manage. Numerous treatments have reportedly been used for the treatment of DD, with limited success. Systemic retinoids are considered the drug of choice for treating DD. However, their use is limited by potential ...