This study identifies BNIP3L as the key regulator of p53-dependent cell death mechanism in colon cancer cells targeted by the novel gallium based anticancer drug, KP46. KP46 specifically accumulated into mitochondria where it caused p53-dependent morphological and functional damage impairing mitochondrial dynamics and bioenergetics. Furthermore, competing with iron for cellular uptake, KP46 low...

This article aims to provide an update of the reliability aspects research on power electronic components and hardware systems. It introduces latest advances in understanding failure mechanisms, testing methods, accumulated damage modeling, mission-profile-based prediction. Component-level examples (e.g., Si IGBT modules, SiC MOSFETs, GaN devices, capacitors, magnetic components) are used for i...

Although Alzheimer’s disease (AD) characterized by progressive deterioration in cognitive function was first described over 100 years ago, there is still no suitable biomarker for diagnosing AD in easily collectable samples (e.g. blood plasma, saliva and urine). Stroke patients often suffer from post-stroke cognitive impairment, or even from post-stroke dementia (PSD) [1]. Recently, excess form...

introduction: patients administered with a therapeutic dose of 131i for thyroid cancer treatment are potential sources of unacceptably high radiation exposure to other individuals, particularly the patient's immediate family members. the aim of this study is to investigate effects of early liothyronine consumption after radio-iodine therapy on accumulated dose and exposure rate in patients with...

Why are you reading this abstract? In some sense, your answer will cast the exercise as valuable-but what is value? In what follows, we suggest that value is evidence or, more exactly, log Bayesian evidence. This implies that a sufficient explanation for valuable behavior is the accumulation of evidence for internal models of our world. This contrasts with normative models of optimal control an...

Standard scene reconstruction methods attempt to determine the positions which visible elements of the environment occupy in space. Instead of determining where things are, we choose to model where things are not. We model the open space in a scene. This is accomplished by tracking a human participant moving in the environment. Based on the position of the tracked object and where it is visible...

The seismic assessment of reinforced concrete (RC) structures before and after retrofitting is a challenging task, mainly because existing numerical tools cannot accurately model the evolution damage. This article proposes an innovative method suitable to assess ultimate carrying capacity RC structures. modelling approach steel constitutive material with damage factor that accounts for accumula...

Oxidative DNA damage causes blocks and errors in transcription and replication, leading to cell death and genomic instability. Although repair mechanisms of the damage have been extensively analyzed in vitro, the actual in vivo repair processes remain largely unknown. Here, by irradiation with an UVA laser through a microscope lens, we have conditionally produced single-strand breaks and oxidat...

In senescent cells, a DNA damage response drives not only irreversible loss of replicative capacity but also production and secretion of reactive oxygen species (ROS) and bioactive peptides including pro-inflammatory cytokines. This makes senescent cells a potential cause of tissue functional decline in aging. To our knowledge, we show here for the first time evidence suggesting that DNA damage...