Musculoskeletal system pathology is one of the main causes morbidity and disability worldwide. Inflammation plays leading role in genesis these diseases. Pain most important factor to a critical decrease quality life limitation daily activities. Most current international guidelines for treatment acute chronic low back neck pain, osteoarthritis, rheumatoid arthritis other diseases recommend ora...

Non-steroidal Anti-inflammatory drugs (Aceclofenac, Mefenamic acid) have conjugated with different antioxidants such as Thymol, Menthol which having antiulcerogenic activity with the NSAIDsantioxidant mutual prodrug gastro sparing NSAIDs devoid of Ulcerogenic side effects. Two mutual Prodrugs have synthesized in which NSAIDs have been conjugated with different antioxidants by a glycolic acid sp...