(-)-Epigallocatechin-3-gallate (EGCG) is the most abundant catechin with various biological activities found in tea. In this study, the effects of EGCG on the metabolism and toxicity of acetaminophen in rat liver were investigated. Male Sprague-Dawley rats were fed a controlled diet without or with EGCG (0.54 %, w/w) for 1 week and were then intraperitoneally injected with acetaminophen (1 g/kg...

Because aspirin (ASA) is often reported to have an adverse effect on pulmonary function in children with chronic asthma, acetaminophen is commonly used as an ASA substitute in these children. To study acetaminophen effects on pulmonary functions, double-blind, oral challenges of ASA (600 mg), acetaminophen (600 mg), or lactose were administered on separate days to 25 chronic asthmatics, ten boy...

Acetaminophen is widely used as a fever and pain reliever drug. However, acetaminophen intoxication was common responsible for thousands of acetaminophen-induced liver injury (AILI) cases worldwide. It understood that glutathione (GSH) depletion causes deposit metabolites which are toxic to cells. N-acetylcysteine (NAC), therapy, has been reported cause side effects such nausea, vomiting, anaph...

BACKGROUND Opioid utilization for acute pain has been associated with numerous adverse events, potentially resulting in longer inpatient stays and increased costs. OBJECTIVE To examine the effect of intravenous (IV) acetaminophen administered intraoperatively on postoperative opioid consumption in adult subjects who underwent hip or knee replacement. METHODS This retrospective cohort study ...

background: the role of premedication with acetaminophen on postoperative conditions in pediatric patients is not well known. we aimed to assess the effects of prophylactic oral versus rectal acetaminophen on postoperative conditions in pediatric adenotonsillectomy patients. methods: in a double-blinded randomized clinical trial, 127 children undergoing adenotonsillectomies were randomized to r...

conclusions intravenous acetaminophen reduced pain following outpatient urological surgery more significantly than meperidine. patients and methods in a prospective, randomized, double-blind clinical trial, 100 outpatients of urological surgery were studied in two groups of acetaminophen (a) and meperidine (m). patients in group a received 1g of acetaminophen in 100 ml saline within 15 minutes ...

The potential protective effect of coenzyme Q10 against acute liver injury induced by a single dose of acetaminophen (700 mg/kg, p.o.) was investigated in rats. Coenzyme Q10 treatment was given as two i.p. injections, 10 mg/kg each, at 1 and 12 h following acetaminophen administration. Coenzyme Q10 significantly reduced the levels of serum aminotransferases, suppressed lipid peroxidation, preve...

The pharmacokinetics of acetaminophen was investigated following oral dosing to Shiba goats in order to evaluate the properties of gastric emptying. Acetaminophen was intravenously and orally administered at 30 mg/kg body weight to goats using a crossover design with a 3-week washout period. The stability of acetaminophen in rumen juice was also assessed. Acetaminophen concentrations were measu...

In non-febrile mouse models, high dose acetaminophen administration causes profound hypothermia. However, this potentially hazardous side-effect has not been confirmed in non-febrile humans. Thus, we sought to ascertain whether an acute therapeutic dose (20 mg⋅kg lean body mass) of acetaminophen would reduce non-febrile human core temperature in a sub-neutral environment. Ten apparently healthy...