We assessed the effect of inhaled platelet-activating factor (PAF) on tracheobronchial clearance, pulmonary function and blood pressure in seven healthy volunteers. After inhalation of 500 micrograms of PAF, retention of radioaerosol in ciliated airways measured at 4 h was 80% higher than in the control recording, and the clearance was reduced by 33% (p less than 0.005). Acetylsalicylic acid (A...

Among the natural macromolecules potentially used as the scaffold material in hydrogels, xylan has aroused great interest in many fields because of its biocompatibility, low toxicity, and biodegradability. In this work, new pH and thermoresponsive hydrogels were prepared by the cross-linking polymerization of maleic anhydride-modified xylan (MAHX) with N-isopropylacrylamide (NIPAm) and acrylic ...

Different parts of Irvingia gabonensis are used ethno-medicinally in some West Africa culture the treatment pain. The stem bark has been reported literature to possess analgesic property. In order evaluate potential seed extract and phytochemicals that may be responsible for this effect. This study was aimed at determining phytochemical contents effect I. gabonensis. screened using standard pro...

Mixtures of the three major metabolites of acetylsalicylic acid (salicylic, gentisic and salicyluric acid) were analyzed by synchronous molecular fluorescence spectroscopy. Three-way data matrices were generated by acquisition of spectra as a function of the pH (between 2 and 11) and of different relative concentrations of the three components. The PARAFAC trilinear model, without restrictions ...

objective(s) the present study was undertaken to investigate the nociception activity of promethazine, a tranquillizer devoid of hypnotic activity in mice. materials and methods antinociception was evaluated, using the acetic acid-induced writhing, tail flick, hot plate and formalin pain tests. results promethazine (4 and 6 mg/kg) and acetylsalicylic acid (100 mg/kg) produced a significant inhi...

In nonstimulated rabbit gastric glands, acetylsalicylic acid (10-500 microM) and indomethacin (3-300 microM) did not significantly modify the basal rate of acid secretion, whereas diclofenac and piroxicam (10-1,000 microM each) caused a marked and dose-dependent inhibitory effect (EC(50) = 138 and 280 microM, respectively). In gastric glands stimulated by histamine (100 microM), diclofenac also...