The effects of mangiferin on uric acid excretion, kidney function and related renal transporters were investigated in hyperuricemic mice induced by potassium oxonate. Mice were divided into normal control group, and 5 hyperuricemic groups with model control, 50, 100, and 200 mg x kg(-1) mangiferin, and 5 mg x kg(-1) allopurinol. Mice were administered by gavage once daily with 250 mg x kg(-1) p...

When administered to rats, various drugs of widely different chemical structures, for example barbiturates, Chloretone, and paraldehyde, markedly increase the urinary excretion of L-ascorbic acid (1). A previous turnover rate study showed that this increase results from an acceleration in the rate of synthesis of L-ascorbic acid (2), but there is no understanding of the mechanism by which drugs...

Sodium taurolithocholate and sodium taurocholenate were infused intravenously into rats and hamsters. Each bile acid salt was given alone or in combination with varying amounts of a primary bile salt, either sodium taurocholate or sodium taurochenodeoxycholate. Bile flow, total bile acid salt excretion, and the excretion of sodium taurolithocholate were quantitatively determined. In addition, m...

The article presents current data on the effect of drugs for treatment gout composition and function intestinal microbiota. potential possibilities pre- probiotics use prevention complex therapy are discussed, therapeutic may be associated with their impact uric acid synthesis excretion, as well anti-inflammatory properties. need further research in this area is emphasized.

Urinary excretion of tryptophan and niacin metabolites was measured before and after oral loads of 2.0 g L-tryptophan in 12 normal smokers, in the same subjects after having stopped smoking for 3 weeks, and again after resumption of smoking. The metabolites measured were kynurenine, hydroxykynurenine, kynurenic acid, xanthurenic acid, acetylkynurenine, o-aminohippuric acid, anthranilic acid glu...

The effects of recombinant human growth hormone (GH, 0.1 U ⋅ kg body wt-1 ⋅ 12 h-1) on systemic and renal acid-base homeostasis were investigated in six normal subjects with preexisting sustained chronic metabolic acidosis, induced by NH4Cl administration (4.2 mmol ⋅ kg body wt-1 ⋅ day-1). GH administration increased and maintained plasma bicarbonate concentration from 14.1 ± 1.4 to 18.6 ± 1.1 ...

Arachidonic acid is a major fatty acid that can be metabolized by the cytochrome P450 enzyme to a number of bioactive eicosanoids. A major metabolite of this oxidation is 20-hydroxyeicosatetraenoic acid, which acts as a potent vasoconstrictor. However, in the kidney, its vasoconstrictor actions can be offset by its natriuretic properties. A guanine-to-adenine polymorphism in the CYP4F2 gene was...

High dietary protein imposes a metabolic acid load requiring excretion and buffering by the kidney. Impaired acid excretion in CKD, with potential metabolic acidosis, may contribute to the progression of CKD. Here, we investigated the renal adaptive response of acid excretory pathways in mice to high-protein diets containing normal or low amounts of acid-producing sulfur amino acids (SAA) and e...

The effect of a low fat containing elemental diet (Vivonex) on faecal bile acid excretion was studied in six patients with cholerheic diarrhoea, two normal controls, and four patients with non-cholerheic diarrhoea. The total faecal bile acid excretion for the patients with bile acid-induced diarrhoea was significantly reduced fron 6-37+/- 1-64 mmol/24 h (mean +/- SEM) to 2-70 +/- 1-12 mmol/24 h...

The urinary excretion of tritiated folic acid after a single intravenous injection in man has been measured by Johns, Sperti, and Burgen (1). Plasma concentrations of the labeled compound fell sharply initially, and then more slowly. Urinary clearance in terms of the later, slowly declining plasma levels was shown, at plasma concentrations above 10 jug per L, to be independent of plasma level a...