The first structurally authenticated [2+2] cycloaddition products of any transition metal hydrazide complexes are reported; cycloaddition products of transition metal hydrazides with alkynes and heteroalkynes have been obtained for the first time; these are the first structurally authenticated cycloaddition products for any transition metal M=NNR(2) functional group.

In this study, we aimed to develop new biologically active compounds with antibacterial properties. 4-amino-5-methyl-2H-1,2,4-triazol-3(4H)-one (1) was converted the corresponding Schiff bases (2) reaction a 4-anis aldehyde. Acetic acid ethyl esters containing [1,2,4] triazole ring (3) were synthesized by condensation of bromoacetate in basic media. The hydrazine hydrate led formation hydrazide...

Benzoylpyridine and nitro benzoic acid hydrazides were used to examine novel Schiff base Co(II), Mn(II), Fe(II), Cu(II) complexes. Elemental analysis, molar conductance, magnetic measurements other methods that like FT-IR, UV–Vis 1H NMR studies have been deduce the nature of bonding structure these These revealed Fe(II) coordinated by four donor atoms in all Free radical scavenging activity was...

8oNicotinic acid hydrazide (isoniazid) has antituberculous activity both in vivo and in vitro (Fox, 1951). In man its principal toxic effect, peripheral neuritis (Biehl & Vilter, 1954; Oestreicher, Dressler & Middlebrook, 1954), can be prevented by the concurrent administration of vitamin B. (pyridoxine) (Biehl & Vilter, 1954; Biehl & Nimitz, 1954). It is of interest to discover whether the spe...

An efficient one-pot tandem cyclization/[3 + 2] cycloaddition reaction of N'-(2-alkynylbenzylidene)hydrazides with ethyl 4,4,4-trifluorobut-2-ynoate under silver triflate-catalyzed or electrophile-mediated conditions is described. Various trifluoromethylated pyrazolo[5,1-a]isoquinolines were afforded in moderate to excellent yield by this developed method.

AIM To synthesize some new azetidin-2-ones of ferulic acid and to evaluate them from physicochemical and spectral point of view. MATERIAL AND METHODS The synthesis was carried out in several steps: (i) obtaining the ferulic acid chloride; (ii) obtaining the ferulic acid hydrazide with hydrazine hydrate (98%); (iii) condensation of ferulic acid hydrazide with different benzaldehydes (2-hydroxy...

We herein describe a simple and metal-free domino methodology to synthesize 2-aminopyrroles from alkynyl vinyl hydrazides. The reaction involves novel propargylic 3,4-diaza-Cope rearrangement tandem isomerization/5-exo-dig N-cyclization reaction. By using this approach, number of with diverse substituents have been prepared.

A method providing a high yield (80–94%) for producing gamma-hydroxy-butanoic acids hydrazides by the interaction of various representatives cyclic esters with 85% hydrazine hydrate has been elaborated. It established that introduction gamma-hydroxypropyl residue into composition results in new biological properties.