D-Amino acid-containing peptides (DAACPs) in animals are a class of bioactive molecules formed via the posttranslational modification of peptides consisting of all-L-amino acid residues. Amino acid residue isomerization greatly impacts the function of the resulting DAACP. However, because isomerization does not change the peptide's mass, this modification is difficult to detect by most mass spe...

In this article we examine four objections to the genetic modification of human beings: the freedom argument, the giftedness argument, the authenticity argument, and the uniqueness argument. We then demonstrate that each of these arguments against genetic modification assumes a strong version of genetic determinism. Since these strong deterministic assumptions are false, the arguments against g...

this study was carried out to investigate the effect of esterification on the surface roughness of eastern cottonwood. eastern cottonwood was modified without using any catalyst and solvent at different temperatures and times with two linear chain carboxylic acid anhydrides (acetic anhydride or propionic anhydride). different weight percentage gains (wpgs) were obtained at different conditions....

it has been shown that enhanced acid secretion can be suppressed in the rat by systemic administration of glucose. we have recently reported that enhancement of acid secretion as a result of pentagastrin was diminished by intragastric administration of d-glucose. present study was designed to investigate whether intragastric d-glucose influences gastric acid secretion associated with carbachol ...

milk and dairy products are in diet almost every day. milk fat contains 70% of saturated fatty acids which can cause an increase in total and low-density lipoprotein cholesterol, and the risk of cardiovascular diseases. therefor, modification of fat composition at dairy products such as yoghurt seems necessary. walnut has high amount of essential fatty acids, anti oxidants and other beneficial ...

Pyroglutamic acid or 5-oxoproline is the cyclic lactam of glutamic acid. Its presence in living cells has been reported from archaebacteria to humans, and its occurrence in living cells has been known for over a century. Despite its almost ubiquitous presence, the role of pyroglutamic acid in living cells is poorly understood. Pyroglutamic acid is found as an N-terminal modification in many neu...

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Modification of erythrocyte membrane sialoglycoprotein(s) in isolated form, or when in membrane, is described using sequential sodium periodate oxidation and tritiated sodium borohydride reduction, essentially as suggested by Van Lenten and Ashwell ((19’71) J. Bio2. Chem. 246, 1889). Conditions of modification were investigated; under the optimal but nondestructive conditions selected, the modi...

Evading the reticuloendothelial system (RES) remains a critical challenge in the development of efficient delivery and diagnostic systems for cancer. Sialic acid (N-acetylneuraminic acid, Neu5Ac) is recognized as a "self" marker by major serum protein complement factor H and shows reduced interaction with the innate immune system via sialic acid-binding immunoglobulin-like lectin (Siglec), whic...