We present a case of a superficial acral fibromyxoma (SAFM) of the distal aspect of the thumb with radiographic evidence of extrinsic pressure erosion of the underlying cortex. This 47-year-old woman presented with a slow-growing mass over the distal aspect of the right thumb that proved to be SAFM on surgical pathology. This is a relatively rare mesenchymal neoplasm of the periungual and subun...

Paraneoplastic acral vascular syndrome involves an association between malignancy and Raynaud phenomenon, gangrene, or acrocyanosis of the fingers. Raynaud phenomenon is a transient digital ischemia resulting from vasoconstriction on exposure to cold temperatures or stressful situations. In its secondary form, it is usually associated with rheumatic disease and rarely occurs as a paraneoplastic...

Tegafur is a prodrug of 5-fluorouracil (5-FU) with a similar spectrum of antitumor activity. It is used in the treatment of advanced gastrointestinal neoplasms. Over 5-FU, tegafur has the advantage of oral administration and less hematologic toxicity. Gastrointestinal toxicity is its main dose-limiting factor. The cutaneous adverse effects of tegafur include mucositis, photosensitivity, diffuse...

Paraneoplastic acral vascular syndrome involves an association between malignancy and Raynaud phenomenon, gangrene, or acrocyanosis of the fingers. Raynaud phenomenon is a transient digital ischemia resulting from vasoconstriction on exposure to cold temperatures or stressful situations. In its secondary form, it is usually associated with rheumatic disease and rarely occurs as a paraneoplastic...

An Bras Dermatol. 2017;92(4):584-95. lobulated, of benign behavior, but which can persist or recur if it is excised in an inadequate manner, being recommended the complete excision of the lesion and postoperative follow-up.2,3 Nail bed is involved in 50% of the cases, and can rarely have a history of trauma preceding the onset of the lesion. Less frequent locations have already been described a...

CASE REPORT A 47-year-old Caucasian man presented to the dermatology department for evaluation of a mass on his left foot. Six years prior, the patient had dropped a sledgehammer on his left great toe causing significant toenail damage, nail loss, and enlarging ulceration despite meticulous wound care. Ten months before presentation, the patient noted rapid growth of the left great toe mass tha...

The patient presented symmetrical, erythematousviolaceous plaques on the distal phalanges of the fingers and toes; the plaques had a hyperkeratotic and desquamative surface (Figures 1 and 2). There was also slight reddening and desquamation of the lobes of the ears. In addition, the patient was asthenic, with mild jaundice of the skin and mucosas, and presented hepatomegaly and palpable right l...

Aim: The aim of our study was to determine the effectiveness and safety of remote ischaemic conditioning (RIC) in combination with i.v. prostavasin as a method of treatment for patients with peripheral acral vasculopathy, presenting as critical ischemia of the digitals of upper and lower limbs at the time of presentation with either surgical nor interventional treatment option Method: 33 patien...