Actinic keratoses (AKs) are evolving malignant cutaneous neoplasms. They are also known as solar keratosis, squamous cell carcinoma in situ-solar keratotic type, or keratinocytic intraepidermal neoplasia. Actinic keratoses can be treated by two general methods: by physical/destructive methods and with topical therapies. This article will review current and evolving topical therapeutic options f...

INTRODUCTION It is important to identify subgroups within the general population that have an elevated risk of developing cutaneous melanoma because preventive and early-detection measures are useful in this setting. The findings of most studies that have evaluated risk factors for cutaneous melanoma are of limited application in Spain because the populations studied have different pigmentary t...

In consideration of the development treatment options for squamous cell carcinoma (SCC), Japanese Skin Cancer Society issued first guidelines SCC in 2007 and revised them 2015. Here, we report English version 2020 edition guidelines. The half this article is an overview including actinic keratosis Bowen’s disease, second discusses three clinical questions: (i) keratosis; (ii) determination rese...

Actinic keratosis (AK) is a common dermatological disorder on sun-exposed skin. Its premalignant condition is widely known; therefore both treatment and protection from sunlight are needed to prevent malignant transformation. Field and lesiontargeted therapies can be combined to search a synergistic effect. Here we report our experience with cryotherapy and ingenolmebutate used sequentially, wi...

LM: Lentigo maligna pAK: pigmented actinic keratosis RCM: reflectance confocal microscopy M elanoma on sun-damaged skin, commonly known as lentigo maligna (LM, akin to melanoma in situ) and lentigo maligna melanoma (akin to invasive melanoma), is mostly found on the head and neck of elderly patients. This type of melanoma, particularly when found early, may be difficult to diagnose on clinical ...

Copyright: © 2014 Puig S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Field Cancerisation Improvement with Topical Application of a FilmForming Medical Device Containing Photolyase and UV Filters in...

To investigate the function of trichohyalin during terminal differentiation of the skin, immunohistochemical studies were performed on trichohyalin and its related proteins, filaggrin and involucrin, the components of the cornified cell envelope. In skin disorders unrelated to tumours, weak trichohyalin expression was found in a few granular cells or in the horny layer of psoriasis, ichthyosis,...

Actinic keratoses are areas of intraepithelial neoplasia for which treatment is necessary. Because they arise in areas of sun damage, it is desirable to treat the entire damaged field to not only treat visible lesions, but also subclinical, emerging malignancies, ie, "field therapy", 5-fluorouracil, imiquimod, and diclofenac are all treatment options, and are discussed and compared.

Open Access. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/ by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and...