The introduction of clinical genome-wide sequencing raises complex issues regarding the management of incidental findings. However, there is a lack of empirical studies assessing views of providers involved in potential disclosure of such findings. In an anonymous survey of 279 clinical genetics professionals, we found that the vast majority of participants agreed that they were interested in k...

Punitive damages are a controversial remedy in Canadian and non-Canadian law. Some scholars have gone so far as to argue that punitive damages are entirely inconsistent with the goals and principles of private law and ought to be abolished. Notwithstanding these criticisms, the Supreme Court of Canada has treated punitive damages as a relatively uncontroversial private law remedy. However, the ...

RON mutations might identify actionable targets in highly aggressive lung tumours http://ow.ly/RTUp30hSBX6.

BACKGROUND Whether for team training, research or evaluation, making effective use of simulation-based technologies requires robust, reliable and accurate assessment tools. Extant literature on simulation-based assessment practices has primarily focused on scenario and instructional design; however, relatively little direct guidance has been provided regarding the challenging decisions and fund...

Maritime domain awareness (MDA) of vessel traffic in a large operational area requires automated tools for watchstanders and analysts. Additionally, the users must be able to tailor the tools to keep pace with changing operational needs. Lockheed Martin Advanced Technology Laboratories has fielded web accessible software that enables operators to configure and manage intelligent agents that mon...

As modern supercomputers evolve to exascale, their I/O subsystems are becoming increasingly complex, making optimization of I/O for scientific applications a daunting task. Although I/O profiling tools facilitate the process of optimizing application I/O performance, legacy profiling tools lack flexibility in their level of detail and ability to correlate traces with other sources of data. Addi...

Strategy implementation (SI) is a significant managerial, and organizational challenge as many practitioners struggle to make strategies actionable achieve intended results. Moreover, there no unified body of research on SI. This problematic for academics aiming contribute research-based knowledge implementation. To remedy this problem, we draw the strategy-as-practice perspective conceptualize...

With the vast amount of immunological data available, immunology research is entering the big data era. These data vary in granularity, quality, and complexity and are stored in various formats, including publications, technical reports, and databases. The challenge is to make the transition from data to actionable knowledge and wisdom and bridge the knowledge gap and application gap. We report...

The use of analytics to support learning has been increasing over the last few years. However, there is still a significant disconnect between what algorithms and technology offer and what everyday instructors need to integrate actionable items from these tools into their learning environments. In this paper we present the evolution of the Student Relationship Engagement System, a platform to s...

A large consumer-software company was struggling to manage a seemingly unmanageable, high-cost technicalsupport call center. The company used “OR process skills” to transform the call center into a strategic asset. By focusing on executive priorities, personally observing business processes, engaging with frontline workers, and directly examining the sources of important data, we discovered the...