OBJECTIVE Emerging evidence suggests that protease-activated receptors-1 and -2 (PAR1 and PAR2) can signal together in response to proteases found in the rapidly changing microenvironment of damaged blood vessels. However, it is unknown whether PAR1 and PAR2 promote or mitigate the hyperplastic response to arterial injury. Using cell-penetrating PAR1 pepducins and mice deficient in PAR1 or PAR2...

The objective was to determine whether recombinant bovine somatotropin (rbST) enhanced live performance,skeletal muscle biological activity, and beta-adrenergic receptor expression of feedlot heifers during the finishing phase. Heifers (n = 16; initial body weight 457 ± 3 kg) were randomly assigned pens (4 pens/treatment; 2 heads/pen) treatment: (1) no rbST (Control); (2) 500 mg/hd sometribove ...

Intra-abdominal infection after curative surgery for colorectal cancer is a serious complication associated with an increased risk of recurrence. Lipopolysaccharides (LPS)—an essential component the cell wall Gram-negative bacteria—were found to exert protumorigenic effect by stimulating inflammatory pathology and formation neutrophil extracellular traps (NETs). This study was conducted test wh...

Rehmannia glutinosa extracts have profound medicinal value in the treatment of liver diseases. It contains micro ribonucleic acid molecules that an average 21 nucleotides. These acids are responsible for gene regulation and expression during The study's main objective is to screen active ingredients its mechanism action treating Our study used omnibus database obtain datasets associated with GS...