MAP is the problem of nding a most probable instantiation of a set of variables in a Bayesian network, given some evidence. MAP appears to be a signiicantly harder problem than the related problems of computing the probability of evidence (Pr), or MPE (a special case of MAP). Because of the complexity of MAP, and the lack of viable algorithms to approximate it, MAP computations are generally av...

The primary intent of the present paper is to adapt familiar notions of algebraic topology, such as the fundamental group, homology, and cohomology to the context of algebraic maps and their (ramified) covering projections. The notion of a principal derived map is already fairly well understood in terms of the defining voltages; however, once it is recognized that voltages are essentially cohom...

Mitogenic G protein-coupled receptors, such as those for lysophosphatidic acid (LPA) and thrombin, activate the Ras/MAP kinase pathway via pertussis toxin (PTX)-sensitive Gi, tyrosine kinase activity and recruitment of Grb2, which targets guanine nucleotide exchange activity to Ras. Little is known about the tyrosine phosphorylations involved, although Src activation and Shc phosphorylation are...

Lipopolysaccharide (LPS), a highly conserved component of the outer membrane of gram-negative bacteria, stimulates macrophages to release various cytokine and eicosanoid mediators of the immune response. The mechanism by which LPS stimulates these cells is poorly characterized. One of the most rapid LPS-stimulated events is the phosphorylation and activation of the p42 and p44 isoforms of mitog...

Erythropoietin (EPO), a major regulator of erythroid progenitor cells, is essential for the survival, proliferation, and differentiation of immature erythroid cells. To gain insight into the molecular mechanism by which EPO functions, we analyzed the activation of Jun N-terminal kinases (JNKs) and extracellular signal-regulated kinases (ERKs) in HCD-57 cells, a murine erythroid progenitor cell ...

A novel mitogen-activated protein (MAP) kinase signaling pathway has been identified in tobacco. This pathway is developmentally regulated during pollen maturation and is activated by hydration during pollen germination. Analysis of different stages of pollen development showed that transcriptional and translational induction of MAP kinase synthesis occurs at the mid-bicellular stage of pollen ...