The relationship between hypertension and diabetic peripheral neuropathy (DPN) has recently been reported in clinical research, but it remains unclear whether hypertension is a risk factor for DPN. To investigate the effects of hypertension on DPN, we analyzed morphological features of peripheral nerves in diabetic rats with hypertension. Male WBN/Kob rats were divided into 2 groups: alloxan-in...

A carrier-system specifically involved in transporting AdN has been shown to exist in mitochondria isolated from a variety of eukaryotic cells. This translocase which is inhibited by atractyloside is located in the inner membrane of these organelles and operates by catalyzing an exchange of endogenous with exogenous AdN; generally ADP is exchanged at a rate greater than that of ATP (for review ...

De Paula, Patrı́cia M., Jaci A. Castania, Leni G. H. Bonagamba, Hélio C. Salgado, and Benedito H. Machado. Hemodynamic responses to electrical stimulation of the aortic depressor nerve in awake rats. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R31–R38, 1999.—Changes in mean arterial pressure (MAP), heart rate (HR), and vascular resistance (hindquarter and mesenteric territori...

Several regions in the rat brain contain neurons known as head-direction cells, which fire only when the rat's head is facing in a specific direction. Head-direction cells are influenced only by the direction of the head with respect to the static environmental surroundings, and not by the position of the head relative to the body. Each head-direction cell has its own preferred direction of fir...

Homologous recombination is one of the major pathways for repairing DNA double strand breaks, the most deleterious of DNA lesions. Recent studies suggest that DNA methylation events target homologous recombination segments; however, the underlying mechanism of DNA methylation during homologous recombination is not understood. In this work, we show that GADD45α, a protein involved in cell cycle ...

This paper presents three types of primary program dependences in concurrent logic programs, and a dependence-based representation named the argument dependence net (ADN) to explicitly represent these program dependences in a concurrent logic program. The ADN can be used as an underlying representation for developing software engineering tools for concurrent logic programs.

BACKGROUND Angiotensin receptor blockers (ARBs) are reported to provide direct protection to many organs by controlling inflammation and decreasing oxidant stress in patients without arteriosclerosis. This study aimed to evaluate (1) whether an ARB (candesartan) decreases values for inflammatory parameters in hypertensive patients with type 2 diabetes mellitus of long duration accompanied by ar...

BACKGROUND Inflammation-induced microglia activation and increased oxidative stress have been observed in neurodegenerative disorders, such as Parkinson's disease. The aim of our study was to determine the appropriate dose and route of LPS administration to study hydroxyl radical generation and extracellular level of dopamine (DA), glutamate (GLU) and adenosine (ADN) in the rat striatum as mark...