A B S T R A C T Introduction: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied the effect of mitochondrial KATP channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. Materials & Methods: Rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with...

Tomorrow's contest between the Albany State Great Danes and the Brockport State Golden Eagles finds both teams looking for their first win of the season. With the two offenses combined having scored only 19 total points in four games, and the Danes still looking to put the ball in the end zone for the first time this year, both teams will have new field generals when they play on University Fie...

Narcotics Tranquilizer Medical professionals PGIMER CHD The medical professionals are vulnerable to substances of abuse/addiction due to their ready accessibility to the substances of abuse. Of particular concern is the finding of a lack of gender differences in problematic drinking with the pattern of female addicts drinking rates for women approximating that of men by the end of medical schoo...

In the early 1990s, researchers began looking at potassium channel openers for seizure control. Over the past 10 years, in vitro research and animal studies demonstrated that potassium channel openers could control seizure activity in a dose-dependent way.1-4 Clinical trials are now confirming these findings.5 Among the calcium channel openers that have been studied, the agent retigabine has co...

The sensitivity of K(ATP) channels to high-affinity block by sulfonylureas and to stimulation by K(+) channel openers and MgADP (PCOs) is conferred by the regulatory sulfonylurea receptor (SUR) subunit, whereas ATP inhibits the channel through interaction with the inward rectifier (Kir6.2) subunit. Phosphatidylinositol 4, 5-bisphosphate (PIP(2)) profoundly antagonized ATP inhibition of K(ATP) c...