Bacterial asparaginase (L-Asparaginase amidohydrolase, E.C. 3.5.1.1) is a selective and highly effective chemotherapeutic agent extensively used over the world in first-line treatment of acute lymphoblastic leukemia (ALL), Hodgkin disease, acute myelocytic leukemia, acute melanomonocytic leukemia, chronic lymphocytic leukemia, lymphosarcoma, reticlesarcoma and melanosarcoma (Verma et al., 2007)...

To find drugs suitable for repositioning for use against leukemia, samples from patients with chronic lymphocytic, acute myeloid and lymphocytic leukemias as well as peripheral blood mononuclear cells (PBMC) were tested in response to 1266 compounds from the LOPAC(1280) library (Sigma). Twenty-five compounds were defined as hits with activity in all leukemia subgroups (<50% cell survival compar...

Disregulation of genes making up the mammalian circadian clock has been associated with different forms of cancer. This study aimed to address how the circadian clock genes behave over the course of treatment for both the acute and chronic forms of leukemia and whether any could be used as potential biomarkers as a read-out for therapeutic efficacy. Expression profiling for both core and ancill...

Simian antisera to human leukemia cells were able to distinguish antigens specific for lymphocytic types of leukemia from those expressed on certain myeloid leukemia cells. In this investigation, cells from acute myelomonocytic leukemia patients (AMML) were examined for their membrane-associated leukemia antigens. Simian antisera to both lymphocytic and myelogenous leukemia cells lysed cells fr...

The effects of splenectomy and/or whole-body irradiation of nude mice before xenotransplantation of lymphoid cell lines, lymphoma, and leukemia were studied. Transplantation after whole-body irradiation resulted in the increased "take" rate of three cultured cell lines (two of T-cell-derived acute lymphocytic leukemia and one of B-cell derived acute lymphocytic leukemia) and in the tumorous gro...

Abstract Acute lymphocytic leukemia (ALL) is a rapidly progressive form of more commonly found in children. Individuals nonresponsive to or ineligible for traditional chemotherapy and allogeneic hematopoietic cell transplant turn alternatives like immunotherapies. While promising, current FDA approved immunotherapies ALL have varying efficacy rates. CD8 T dysfunction exhaustion key contributor ...

INTRODUCTION In developing countries, there is commonly a lack of population-based cancer registries or underreporting, thus not recognizing the true dimensions of the problem. AIM To describe the age and sex frequencies of the major subtypes of leukemias in two hospitals of reference in the metropolitan area of Mexico City. MATERIAL AND METHODS This is a descriptive and retrospective study...

Ribosomes were isolated and ribosomal RNA (rRNA) was prepared from leukemic cells derived from the venous blood of patients with acute myeloblastic leukemia, acute undifferentiated leukemia, subacute myelocytic leukemia, chronic lymphocytic leukemia, leukemic lymphosarcoma, leukemic reticuloendotheliosis, a cultured Burkitt lymphoma cell line, and phytohemagglutinin-stimulated normal lymphocyte...