نتایج جستجو برای: acute myeloid leukemia aml
تعداد نتایج: 707792 فیلتر نتایج به سال:
Differentiating chronic myelogenous leukemia in primary blast crisis (CML-BC) from de novo BCR-ABL1-positive acute myeloid leukemia (AML) is a diagnostic challenge with therapeutic consequences. In our case, a basophilia, the presence of the Philadelphia chromosome in all metaphases and the strict exclusion of molecular hallmarks of AML lead us to retain the diagnosis of CML-BC rather than BCR-...
Acute myeloid leukemia (AML) is a severe blood malignancy associated with high relapse rate. The current clinical chemotherapy typically perplexed serious side effects. Here, A6 peptide-tagged, small and reduction-sensitive polymersomal vincristine sulfate (A6-cPS-VCR) reported as novel, smart specific treatment for CD44 positive AML. A6-cPS-VCR stably loaded 3.3 wt% VCR displays size of ≈ 31 n...
In acute myeloid leukemia (AML) and blast crisis (BC) chronic myeloid leukemia (CML) normal differentiation is impaired. Differentiation of immature stem/progenitor cells is critical for normal blood cell function. MicroRNAs (miRNAs or miRs) are small non-coding RNAs that interfere with gene expression by degrading messenger RNAs (mRNAs) or blocking protein translation. Aberrant miRNA expressio...
Canonical NF-κB signaling is constitutively activated in acute myeloid leukemia (AML) stem cells and is required for maintenance of the self-renewal of leukemia stem cells (LSCs). However, any potential role for NF-κB non-canonical signaling in AML has been largely overlooked. Here, we report that stabilization of NF-κB-inducing kinase (NIK) suppresses AML. Mechanistically, stabilization of NIK...
Background: Acute leukemias comprise a heterogeneous group of diseases characterized by rapid and uncontrolled clonal expansion of progenitor cells of the hematopoietic system. Immunophenotyping helps subclassify acute leukemias into subgroups with prognostic implications. Materials and Methods: This descriptive observational cross-sectional study was performed on 80 newly diagnosed cases of a...
Disease alleles that activate signal transduction are common in myeloid malignancies; however, there are additional unidentified mutations that contribute to myeloid transformation. Based on the recent identification of TET2 mutations, we evaluated the mutational status of TET1, TET2, and TET3 in myeloproliferative neoplasms (MPNs), chronic myelomonocytic leukemia (CMML), and acute myeloid leuk...
Molecular classification of acute myeloid leukemia (AML) aids prognostic stratification and clinical management. Our aim in this study is to identify transcriptome-wide mRNAs that are specific each the molecular subtypes AML. We analyzed RNA-sequencing data 955 AML samples from three cohorts, including BeatAML project, Cancer Genome Atlas, a cohort Swedish patients provide comprehensive view su...
Acute myeloid leukemia (AML) is the most common type of acute leukemia. According to the National Cancer Institute, the new cases and deaths from AML in the United States in 2016 are estimated to be approximately 19,990 and 13,400, respectively, with a 5 year survival rate of only about 26.6% (http://seer.cancer.gov/statfacts/html/amyl. html). Thus, there is an urgent need to find more effectiv...
background: global death toll of acute leukemia (al), as a heterogeneous group of hematopoietic malignancies, is rather high, i.e. almost 74% of 300,000 new cases die every year. this reflects a poor prognosis of this malignancy in most parts of the world, where contemporary and rather complex remedies are not available. there are a few well documented reports about the epidemiologic features o...
it has recently been shown that ror1, a member of the receptor tyrosine kinase family, is overexpressed in leukemic b cells of chronic lymphocytic leukemia (cll) and a subset of acute lymphoblastic leukemia (all). in this comparative study the expression profile of ror1 mrna was investigated in iranian patients with cll and acute myelogenous leukemia (aml) and the results were compared with tho...
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