نتایج جستجو برای: acute promyelocytic leukemia
تعداد نتایج: 688410 فیلتر نتایج به سال:
These NCCN Guidelines Insights summarize several key updates to the NCCN Guidelines for Acute Myeloid Leukemia and discuss the clinical evidence that support the recommendations. The updates described in this article focus on the acute promyelocytic leukemia (APL) section, featuring recommendations for additional induction/consolidation regimens in patients with low- or intermediate-risk APL, a...
This session addressed acute promyelocytic leukemia (APL), multiple myeloma, and myelodysplastic syndromes. In particular, arsenic trioxide as a treatment for APL, one of the most highly curable types of acute myeloid leukemia, was discussed. Speakers also discussed the use of combination regimens in clinical trials for multiple myeloma treatments and therapeutic agents in the treatment of myel...
APROMYELOCYTOID” bone marrow and disturbances in fibrinogen are prominent features of a form of leukemia which is characterized by a rapid course, severe hemorrhage and poor response to therapy. This study is based upon 17 patients observed over the past 9 years. The first seven patients in this series were the basis of a brief report’ in 1955 of the occurrence of hypofibrinogenemia in acute le...
We report the clinical features and treatment outcome of 33 patients with multiple sclerosis who developed acute promyelocytic leukemia. Thirty patients were previously exposed to mitoxantrone. The median latency period between treatment initiation and acute promyelocytic leukemia diagnosis was 32 months. The PML-RARA bcr1 iso-form was identified in 87% of cases. Twenty-nine (90%) patients achi...
Aplastic anemia (AA) is a hematological disorder presenting with pancytopenia in peripheral blood and hypocellularity in bone marrow. AA patients with immunosuppressive therapy and granulocyte colony-stimulating factor treatment have a risk of development of acute leukemia including acute myeloid leukemia (M0, M1, M2, M4, M5, M6) and acute lymphoblastic leukemia. However, AA with transformation...
Chromosomal translocations in hematological malignancies often result in novel fusion chimeric genes. We report a case of acute myeloid leukemia with a clonal translocation t(11;12)(p15;q13) displaying morphologic and immunophenotypic features resembling the classical hypergranular subtype of acute promyelocytic leukemia. The gene fused to NUP98 (nucleoporin 98) was detected by comparative geno...
Background: Decitabine (5-aza-2'-deoxycytidine, DAC) is a deoxycytidine analog currently used as an effective drug against myelodysplastic syndromes and acute myeloid leukemia. Although various studies have pointed out the epigenetic effects of this drug, its epigenetic mechanisms in different leukemic cell lines are not specified. In this lab trial study, possible epigenetic effects of decitab...
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