the hematopoietic syndrome is anticipated when a dose of radiation greater than 100 cgy is received. the resulting clinical situation is life-threatening because of opportunistic infections and gradual decline in immune competency due to irradiation. because of evidence of a possible immunomodulatory role for cimetidine, an antagonist of histamine h2 receptors, we studied the effects of this dr...

Severe radiation exposure may cause acute radiation syndrome, a possibly fatal condition requiring effective therapy. Gut microbiota can be manipulated to fight against many diseases. We explored whether intestinal microbe transplantation could alleviate radiation-induced toxicity. High-throughput sequencing showed that gastrointestinal bacterial community composition differed between male and ...

Several candidate drugs for acute radiation syndrome (ARS) have been identified that have low toxicity and significant radioprotective and radiomitigative efficacy. Inasmuch as exposing healthy human volunteers to injurious levels of radiation is unethical, development and approval of new radiation countermeasures for ARS are therefore presently based on animal studies and Phase I safety study ...

concurrence of interstitial nephritis and uveitis named tubulointestitioal nephritis and uveitis syndrome (tinu) are unusual and uncommon presentations of interstitial nephritis. this syndrome is considered after ruling out other differential diagnoses. a-38-year old man presented with acute renal failure and uveitis. the histologic findings of renal biopsy showed acute tubulointestitioal nephr...

A major solar particle event (SPE) may place astronauts at significant risk for the acute radiation syndrome (ARS), which may be exacerbated when combined with other space flight stressors, such that the mission or crew health may be compromised. The National Space Biomedical Research Institute (NSBRI) Center of Acute Radiation Research (CARR) is focused on the assessment of risks of adverse bi...

PURPOSE The purpose of this study was to assess the diagnostic accuracy and one year prognosis of whole chest, "multiple rule out" CT for coronary artery disease (CAD) in Emergency Department patients. METHODS AND FINDINGS One hundred and two Emergency Department patients at low to intermediate risk of acute coronary syndrome (ACS), pulmonary embolism and/or acute aortic syndrome underwent a ...

conclusions termination of pregnancy was performed as it would save the patient’s life in either deteriorated acute severe pancreatitis or hellp. case presentation a 17-year-old female with 27 weeks of gestation presented mild acute pancreatitis. based on the criteria of persistent systemic inflammatory response syndrome (sirs) she subsequently developed severe pancreatitis. bilirubin 2.2 mg/dl...