Bioenergetic dysfunction occurs in Alzheimer's disease (AD) and mild cognitive impairment (MCI), a clinical syndrome that frequently precedes symptomatic AD. In this study, we modeled AD and MCI bioenergetic dysfunction by transferring mitochondria from MCI, AD and control subject platelets to mtDNA-depleted SH-SY5Y cells. Bioenergetic fluxes and bioenergetics-related infrastructures were chara...

IMPORTANCE Current hypothetical models emphasize the importance of β-amyloid in Alzheimer disease (AD) pathogenesis, although amyloid alone is not sufficient to account for the dementia syndrome. The impact of small-vessel cerebrovascular disease, visualized as white matter hyperintensities (WMHs) on magnetic resonance imaging scans, may be a key factor that contributes independently to AD pres...

In this study, we aim to conduct usability tests on different WebMap sites with eye movement analysis. Overall task performance, the effects of iconic representation of information, and the efficiency of pop-up usage were evaluated. The eye tracking technology is used for this study in order to follow the position of the users’ eye-gaze. The results show that there are remarkable differences in...

The aim of this paper is to examine the parallelism between tonal transitions and musical note transitions in Thai pop songs based on the data from 30 current pop songs. The results suggest that there is a statistically significant parallelism between tonal transitions and musical note transitions. Interestingly, the results show that both contour tones, RISING and FALLING, typically pattern wi...

Atopic dermatitis (AD) is a pruritic, relapsing, chronic disease that arises most commonly during infancy, childhood, or adolescence. It is clear that genetic factors are important in AD, a family history of AD, allergic rhinitis, and/or asthma and other “Atopic” phenomena being common in patient with AD. The two main pathogenetic characteristic of AD are: I) IgE-mediated antigen dependent “Spe...

BACKGROUND Early-onset dementia is common in Down syndrome adults, who have trisomy 21. The amyloid precursor protein gene is on chromosome 21, and so is over-expressed in Down syndrome, leading to amyloid β (Aβ) over-production, a major upstream pathway leading to Alzheimer disease (AD). Statins (microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors), have pleiotropic effects i...

Abstract Background Frontotemporal lobar degeneration (FTLD) phenotypes can be associated with Alzheimer’s disease (AD). It is unknown whether differences exist in relationship between markers of such as tau and neurofilament light chain (NFL) cognition FTLD without AD. Method 40 patients were included this study: (A) 31 AD [5 behavioral variant FTD, 11 corticobasal syndrome (CBS), 1 non‐fluent...

We present a new bound for the worldvolume actions of branes with a Wess-Zumino term. For this we introduce a generalization of calibrations for which the calibration form is not closed. We then apply our construction to find the M-5-brane worldvolume solitons in an AdS background that saturate this bound. We show that these worldvolume solitons are supersymmetric and that they satisfy differen...

BACKGROUND This case-control study utilized a population-based dataset to examine the association of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) with prior anxiety disorder (AD) by comparing the risk of prior AD between subjects with CP/CPPS and matched controls in Taiwan. METHODS We study used data sourced from the Taiwan Longitudinal Health Insurance Database. The cases compr...