GCN5 is a histone acetyltransferase (HAT) essential for development in mammals and critical to stress responses in yeast. The protozoan parasite Toxoplasma gondii is a serious opportunistic pathogen. The study of epigenetics and gene expression in this ancient eukaryote has pharmacological relevance and may facilitate the understanding of these processes in higher eukaryotes. Here we show that ...

Results The retrospective analysis of patients allowed to identify 5 patients presenting with a strong clinical suspicion of DADA2. The mean age of disease onset was 12 months (range 6-36). The disease course was chronic in two patients and recurrent in three. All patients presented skin involvement and elevation of acute phase reactants; three patients presented multiple strokes, one patient a...