Introduction It has been said that pigmentation of the skin is the most distinctive feature of Addison's disease (British Medical Journal, 1963) and that no other clinical feature is as useful diagnostically (Dunlop, 1963). Four cases are presented where no pigmentation was found. The difficulties in diagnosis are discussed and it is suggested that Addison's disease without pigmentation is comm...

Primary hypoadrenalism has various causes and protean manifestation. We report a young female patient who presented with severe muscle spasm as her primary complaint. On evaluation she was found to be a case of Addison's disease secondary to adrenal tuberculosis. Her muscle spasm disappeared rapidly with replacement dose of glucocorticoid.

Addison's disease is often accompanied by a number of cardiovascular manifestations. We report the case of a 30-year-old man who presented with a new onset dilated cardiomyopathy due to Addison's disease. The clinical presentation, treatment, and outcomes of this rare hormone mediated cardiac disorder are reviewed.

John Pugh died on 21 June 1976, 40 years, all but one month, after developing Addison's disease. Save for the first three years of this period, he lived a full life both socially and professionally. He developed his illness at a time when the treatment of this disease was in the research stage, so his history is something of a medical saga which his family feel should be put on record if only, ...

Primary medication adherence occurs when a patient properly fills the first prescription for a new medication. Primary adherence only occurs about three-quarters of the time for antihypertensive medications. We assessed patients' barriers to primary adherence and attributes of patient-provider discussions that might improve primary adherence for antihypertensives. In total, 26 patients with inc...

We report two cases of Addison's disease occurring in association with proven Mycobacterium tuberculosis infection. Both were treated with modern chemotherapeutic agents and were shown to have developed normal adrenal cortical function after several years. We suggest that adrenal function should be tested after modern anti-tuberculous therapy of this disease.