Colorectal cancer (CRC) is the second leading cause of death in the United States, claiming 56,730 lives in 2004. 146,940 new cases are diagnosed each year, (age standardized incidence 53/100,000) making it 3rd in American cancer incidence, with a lifetime risk estimate of -61/6. Risk factors for CRC include but are not limited to inherited CRC syndromes, inflammatory bowel disease, diabetes me...

To investigate the role of telomerase in the multistep colorectal carcinogenesis, we examined telomerase activity in 31 adenomatous polyps and 22 paired cancer-normal mucosa specimens from non-hereditary nonpolyposis colorectal cancer patients. Telomerase activity was detected in 18% of normal mucosa, 16% of small (<1.0 cm) polyps, 20% of intermediate polyps, 71% of large (>2.0 cm) polyps, and ...

Colorectal cancer (CRC) is the second most common type of cancer in women and the third most common cancer in men. Currently, it is the third leading cause of cancer death worldwide in women and the fourth leading cause in men. Many studies have demonstrated that the mortality because of CRC can be averted by utilizing preventive strategies to detect and resect precancerous lesions, such as sur...

Rectal prolapse represents full thickness protrusion of the rectum through the anal sphincter. Rarely, the prolapsed portion of the rectum can become neoplastic. The exact incidence of rectal prolapse although unknown, it is a rather rare entity. We hereby report a case of a rectal prolapse with neoplastic change. The present study report the case of a 58-year-old woman, without previous major ...

Every year thousands of people in the USA are diagnosed with small intestine and colorectal cancers (CRC). Although environmental factors affect disease etiology, uncovering underlying genetic factors is imperative for risk assessment and developing preventative therapies. Familial adenomatous polyposis is a heritable genetic disorder in which individuals carry germ-line mutations in the adenom...

BACKGROUND/AIMS A diagnosis of acute diverticulitis is based on computed tomography (CT). Colonoscopy is commonly performed after the acute event to exclude other diagnoses. This study aimed to determine whether colonoscopy is necessary and what additional information is gained from a colonoscopy after acute diverticulitis. METHODS Acute diverticulitis was diagnosed by clinical criteria and c...