The main physiologic function of adipokines on the energy metabolism and cardiovascular homeostasis, among others, are well known. In last years, our laboratory is providing increasing evidence about possible role as mediators vascular damage, by inducing different pro-inflammatory pro-senescent mechanisms. secretion like visfatin or dipeptidylpeptidase-4 (DPP4) adipose tissue, particularly vis...

Adipose tissue composed of adipocytes, fibroblasts, immune cells, and various other cell types, once known as passive reservoir is now considered an endocrine organ secreting bioactive molecules including hormones now termed adipokines with various known and unknown endocrine functions in addition to regulating fat mass and nutrient homeostasis. Due to the dramatic rise in obesity and its metab...

BACKGROUND Obesity is associated with low-grade chronic inflammation attributed to dysregulated production, release of cytokines and adipokines and to dysregulated glucose-insulin homeostasis and dyslipidemia. Nutritional interventions such as dieting are often accompanied by repeated bouts of weight loss and regain, a phenomenon known as weight cycling (WC). METHODS In this work we studied t...

OBJECTIVE Coronary artery disease (CAD) is associated with abdominal obesity and metabolic syndrome. Adipocytes secrete adipokines, including the newly discovered adipocyte fatty acid binding protein (A-FABP) and chemerin. Adipokines contribute to the pathogenesis of CAD. In patients with CAD, the presence of significant ischemia predicts adverse outcomes. It is unknown whether adipokines can b...

Dysregulation of adipose tissue-derived bioactive molecules, termed adipokines, is recognized as common ground for insulin resistance and metabolic syndrome associated with obesity. However, adipokine dysregulation is paradoxically associated with lipodystrophy and lipoatrophy with aging. In familial partial lipodystrophic syndromes and Hutchinson-Gilford progeria syndrome, both of which are ca...

Abstract Adiponectin and leptin are adipokines, secreted by white adipose tissue (WAT), which play an important role in energy homeostasis. Some evidence has shown that adipokine‐producing cells present the bone marrow (BM) appear to exert influence on hematopoiesis B cell development. Common variable immunodeficiency (CVID) is one of most common inborn errors immunity humans. In CVID, numerica...