Background: Concomitant oral administration of NFX with TNZ may affect NFX absorption and consequently its blood concentration and pharmacological effect. Objective: The present study was undertaken to investigate the effect of TNZ on the pharmacokinetics of NFX in healthy volunteers. Methods: This study was conducted as an open-label, randomized, two-way crossover experimental design. After an...

Background: Concomitant oral administration of NFX with TNZ may affect NFX absorption and consequently its blood concentration and pharmacological effect. Objective: The present study was undertaken to investigate the effect of TNZ on the pharmacokinetics of NFX in healthy volunteers. Methods: This study was conducted as an open-label, randomized, two-way crossover experimental design. After an...

background: for more than four decades clomiphene citrate has been the first line of the treatment for ovulatory disorders. the aim of this study was to compare the effects of letrozole and clomiphene citrate on ovulation and pregnancy rate in patients with polycystic ovary syndrome.   methods: in this prospective double-blind study, 100 patients with polycystic ovary syndrome were randomized i...

background: the most appropriate route of tranexamic acid administration is controversial. in the current study, we compared the efficacy of intravenous (iv) and topical intra-articular tranexamic acid in reducing blood loss and transfusion rate in patients who underwent primary total knee arthroplasty. methods: one hundred twenty 120 patients were scheduled to undergo primary total knee arthro...

PURPOSE We wished to determine the extent of absorption of gabapentin (GBP) after rectal administration to children on maintenance therapy. METHODS Two children scheduled for extensive surgery received GBP rectally and orally. A pharmacokinetic profile was derived after each route of administration. RESULTS Serum GBP levels after rectal administration decreased at a rate similar to their ra...

The effect of the injection site on the pharmacokinetics of phenol red and bromphenol blue as model drugs after intraperitoneal (i.p.) administration into rats was examined. Their absorption rate from the peritoneal cavity was faster after i.p. administration to the liver surface (LS) than that after i.p. administration to the distal small intestine (SI), as shown by the increase in maximum con...

the present study investigates the effects of different routes of inulin administration as prebiotic on gut microbiota and survival rate of indian white shrimp post-larvae. four hundred and fifty indian white shrimp post-larvae (pl1) were stocked in nine tanks. the tanks were assigned into three treatments: feeding with inulin-treated (110 mg l-1) artemia nauplii (i-t), feeding with inulin-enri...