Glaucoma is a neurodegenerative disease of the optic nerve characterized by progressive loss of retinal ganglion cells (RGCs), which can lead to irreversible blindness. Numerous factors have been implicated in the disease, with high intraocular pressure (IOP), coupled with advanced age, being major risk factors. Other factors include ischemia, generation of reactive oxygen species, a genetic pr...

PURPOSE To compare the optic disc parameters of glaucomatous eyes to those of non-glaucomatous eyes with large discs. METHODS We studied 225 consecutive eyes with large optic discs (>2.82 mm2): 91 eyes with glaucoma and 134 eyes without glaucoma. An eye was diagnosed with glaucoma when visual field defects were detected by the Humphrey Field Analyzer. All of the Heidelberg Retina Tomograph II...

PURPOSE To assess the cortical structure and cerebral blood flow changes in the brain of patients with primary open-angle glaucoma (POAG). METHODS High-resolution anatomical magnetic resonance imaging (MRI) and arterial spin labeling (ASL)-MRI were performed in 23 POAG patients and 29 controls. Patients were further divided into early-moderate and advanced groups based on mean deviation (MD) ...

OBJECTIVES To compare methods to estimate the incidence of visual field progression used by 3 large randomized trials of glaucoma treatment by applying these methods to a common data set of annually obtained visual field measurements of patients with glaucoma followed up for an average of 6 years. METHODS The methods used by the Advanced Glaucoma Intervention Study (AGIS), the Collaborative I...

Prior glaucoma severity staging systems were mostly concerned with visual field function and retinal nerve fiber layer, but did not include intraocular pressure or medications to capture resistance to treatment. We recently introduced a simple index that combines pressure, medications, and visual field damage and applied it to stratify outcomes of trabectome surgery. In the analysis presented h...

ABSTRACT: Glaucoma is a chronic eye disease that leads to vision loss. Detecting glaucoma in time is critical. The symptoms of the glaucoma disease occur when it is in advanced stage. Hence, glaucoma is called the silent thief of sight. Detecting the disease in time is very important. In this project, an optic disc and optic cup segmentation is used to identify the glaucoma disease in time. In ...

Prior glaucoma severity staging systems were mostly concerned with visual field function and retinal nerve fiber layer, but did not include intraocular pressure or medications to capture resistance to treatment. We recently introduced a simple index that combines pressure, medications, and visual field damage and applied it to stratify outcomes of trabectome surgery. This microincisional glauco...

Purpose Glaucoma-related molecular biomarkers can improve clinical testing to diagnose the disease early, predict its prognosis, and monitor treatment responses. Based on the evidence of increased oxidative stress in glaucomatous tissues, this study analyzed oxidative stress-related biomarker candidates in blood and aqueous humor samples with or without glaucoma. Methods The blood and aqueous...

Aim to evaluate the efficacy and safety of micropulse transscleral cyclophotocoagulation (MP-TSCPC) modality in patients with early stages glaucoma.
 Material methods. We examined 38 stage primary open-angle uncompensated glaucoma (POAG) (17 stage, 18 advanced stage) before during 12 months after MP-TSCPC treatment (SUPRA device 810, Quantel Medical, France) using modified laser parameters...