Inflammation is defined as the local response of living mammalian tissues to injury due to any agent. Inflammation involves 2 basic processes early inflammatory response later followed by healing. There are two types of inflammation, Acute and Chronic. Acute inflammation is of short duration and represents the early body reaction, resolves quickly and is usually followed by healing. Chronic inf...

The multiplication of Plasmodium falciparum in culture, as measured by [3H]hypoxanthine incorporation, was inhibited in a dose-dependent manner by rabbit tumor necrosis serum. The regimen by which tumor necrosis serum is produced caused significant increases in the levels of triglycerides and lipid peroxides, with the latter being indicated by the level of malondialdehyde in the serum. When tum...

Antibiotics are not chemically stable in water based oral pharmaceutical suspensions. Anhydrous liquid antibiotic suspension for oral administration provides a product having good shelf life and taste characteristics relative to conventional liquid formulations. A ready to use oil based cefpodoxime proxetil preparation which can be stored at room temperature was prepared and evaluated for its o...

In this study, an optimized nanodispersible oral dosage form (containing a lactate ester) was developed for cilostazol (CZL). CZL is a phosphodiesterase inhibitor used for intermittent claudication. We aimed to improve the dissolution rate and absorption of CZL giving it a better chance of oral bioavailability, and to evaluate its stability on storage. Suitable compositions of nanoemulsion prec...

We examined the phase behavior of various polyoxyethylene sorbitan fatty acid ester (polysorbates)/ethanol/isopropyl myristate (IPM)/150 mM NaCl solution (NaClaq) systems in order to prepare a microemulsion containing a low ratio of ethanol, which is more suitable for in vivo application. Using polyoxyethylene sorbitan trioleate (Tween 85), which has a large lipophilic moiety, as a surfactant c...

Analysis of the roles of the short chain fatty acid receptor, free fatty acid 3 receptor (FFA3), has been severely limited by the low potency of its endogenous ligands, the crossover of function of these on the closely related free fatty acid 2 receptor, and a dearth of FFA3-selective synthetic ligands. From a series of hexahydroquinolone-3-carboxamides, we demonstrate that 4-(furan-2-yl)-2-met...

This paper takes a doubting, though friendly, look at the hypotheses of “second generation deciine” and “segmented assimiiation” that have framed the emerging research agenda on the new second generation. We begin with a review of the basic approach, outlining the logic of argument, and specifying the central contentions.We then head toward the past, in search of material that will illuminate b...

A laboratory-scale membrane bioreactor (MBR) was fed with synthetic wastewater to investigate the possibility of simultaneous removal of organic, nitrogen and phosphorus by intermittent aeration. The MBR consists of two compartments using a microfiltration membrane with 0.2 μm pore size and a surface area of 0.35 m2. Hydraulic retention time was set at 24 hours and solid retention time 25 days....

We present measurements of the transverse momentum spectra for K 0 S , Λ , Ξ − and their antiparticles in p+p collisions at √ s = 200 GeV. The extracted mid-rapidity yields and pT are in agreement with previous p + ¯ p experiments while they have smaller statistical errors. We compare the measured particle spectra and pT values to predictions from the PYTHIA leading order pQCD model (v6.221) an...