Nuclear protein import is central to eukaryotic cell function. It is dependent on ATP, temperature and cytosolic factors, and requires specific targeting sequences called nuclear localization signals (NLSs). Nuclear import kinetics was studied in vitro using digitonin-permeabilized cells of the HTC rat hepatoma cell line and a fluorescently labelled beta-galactosidase fusion protein carrying am...

BACKGROUND Due to bacterial resistance to antibiotics there is a need for new antimicrobial agents. In this respect nanoparticles can be used as they have expressed antibacterial activity simultaneously being more reactive compared to their bulk material. The action of zinc (II), titanium (IV), copper (II) and (I) oxides thin films with nanostructured surface and silver nanoscale particles on E...

2014 The results of an investigation by differential reflectivity of the reflectivity change due to the deposition of small amounts of Ag (10 to 200 A) on a cold (140 K) polycrystalline smooth Ag substrate are presented. The modifications of the optical properties due to the roughening of the surface are analysed, the annealing of the deposited Ag overlayers is investigated and their relationsh...

Background Metabolism of the endocannabinoid 2-arachidonoylglycerol (2-AG) yields arachidonic acid (AA), the precursor to proalgesic eicosanoids including prostaglandin E2 (PGE2). Diacylglycerol lipase β (DAGLβ) is an enzyme that synthesizes 2-AG and its inhibition reduces eicosanoid levels and produces antinociceptive effects in models of inflammatory pain. Here we test whether inhibition of D...

We describe the karyotype, location of nucleolus-organizing regions (NORs) and heterochromatin composition and distribution in Lepidochitona caprearum (Scacchi, 1836). The examined specimens had 2n=24 chromosomes; the elements of pairs 1-4 were metacentric, subtelocentric those of the fifth pair, telocentric the elements of other pairs. NOR-FISH, Ag-NOR- and CMA3 banding showed NORs localized o...

Department of Orthopaedic Research & Biotechnology, The Children’s Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia, Discipline of Paediatrics and Child Health, Faculty of Medicine, A27 University of Sydney, NSW 2006, Australia, School of Aerospace, Mechanical and Mechatronic Engineering, J07 University of Sydney, NSW 2006, Australia, Department of Orthopedics, Lund Universi...

1 Department of Civil & Environmental Engineering, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford GU2 7XH, UK 2Department of Civil Engineering, Indian Institute of Technology New Delhi, Hauz Khas, New Delhi 110016, India 3 School of Life Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK 4Nanotechnology and Molecular Sciences, School of Chemistry, Physics an...

Michael S. Zhdanov,1 Hongzhu Cai2 and Glenn A. Wilson3 1Department of Geology and Geophysics, University of Utah, 115 South, 1460 East, Room 383, Salt Lake City, UT 84112, USA, and TechnoImaging, 4001 South, 700 East, Suite 500, Salt Lake City, UT 84107, USA. E-mail: [email protected] 2Department of Geology and Geophysics, University of Utah, 115 South, 1460 East, Room 383, Salt Lake C...