Felodipine is a second generation calcium channel blocker widely used as antihypertensive and antianginal drug which belongs to BCS class II category. Hence, its low water solubility limits the pharmacological effect. The aim of this study was to improve the dissolution rate of felodipine using spherical agglomeration technique with acetone, water and dichloromethane as good solvent, poor solve...

This paper outlines a dynamic model of firm location choice, in an environment which includes both agglomeration effects and stochastic productivity shocks. The model follows closely the methods of Hopenhayn (1992) and his treatment of firm level entry and exit decisions. However, this model adds the complexity of a second location, as well as the existence of spillover effects, or agglomeratio...

Agglomeration Economies, or production cost savings due to geographic clustering of firms and industries, can enhance the growth and development of firms, industries, regions and cities. We provide an overview of the theory and empirical literature of agglomeration, and highlight several applications from the cost function perspective. These applications include cost savings from density in the...

SUMMARY To solve a given ne mesh problem, the design of a multigrid method requires the deenition of coarse levels, associated coarse grid operators and inter-grid transfer operators. For non-structured simplicial meshes, these deenitions can rely on the use of non-nested triangulations. Another possibility is to found these deenitions on agglomeration/aggregation techniques in a purely algebra...

The observation of an unusual light-induced agglomeration phenomenon that occurs besides the trapping of the gold nanoparticles aggregates (GNAs) has been observed. The observed agglomerate has a 60-100 μm donut-shaped metal microstructure with the rate of formation dependent on the laser power used. In this paper, the forces involved and the mechanism of this further agglomeration phenomenon a...

PN187MvGnew Abstract The present study addresses the relevance of geographic proximity for companies in our age of advanced ICT. Many visions of, and speculations on, an increased footlooseness of companies and a concomitant dispersal of urban economic activity have been published in recent years. To identify whether urban agglomeration economies (in particular, knowledge spillovers) are still ...

Fluidized bed agglomeration is used to produce large and porous dry agglomerates with improved instant properties. Water (or binder solution) is sprayed in the fluidized bed of particles to render their surface sticky. The agglomerate growth results from the repetition of different steps (wetting of the particle surface, particles collision and bridging, and drying) and depends on the processin...