Methods and results We compared survival in patients with HF-PEF with that in patients with HF-REF in a meta-analysis using individual patient data. Preserved EF was defined as an EF ≥ 50%. The 31 studies included 41 972 patients: 10 347 with HF-PEF and 31 625 with HF-REF. Compared with patients with HF-REF, those with HF-PEF were older (mean age 71 vs. 66 years), were more often women (50 vs. ...

Acute heart failure (AHF) is a major cause of hospitalizations. Severe dyspnea, pulmonary congestion and low cardiac output with peripheral vasoconstriction and renal hypoperfusion is a main form of clinical presentation. Most patients with acute worsening have a pre-existing decompensated chronic heart failure (ADCHF), but AHF may also occur as a first manifestation of a previously unknown hea...

BACKGROUND More than 25% of Medicare patients hospitalized for heart failure are readmitted within 30 days. The contributions of numeracy and health literacy to recidivism for patients with acute heart failure (AHF) are not known. METHODS AND RESULTS A cohort of patients with acute heart failure who presented to 4 emergency departments between January 2008 and September 2011. Research assista...

Patients manifesting symptomatic pulmonary congestion during an acute myocardial infarction have long been recognized to be at heightened risk of both shortand long-term mortality.1–3 Acute heart failure (AHF) complicates acute myocardial infarction as a result of a complex interaction of structural, hemodynamic, neurohormonal, and genetic maladaptations. Abrupt myocyte loss leading to contract...

Acute heart failure (AHF) is one of the most common causes for hospital admissions across the world and is associated with poor short-term outcomes and high cost. Despite numerous clinical trials focusing on AHF, new therapies largely failed to improve either patients’ symptoms or outcomes and hence are not available to patients. Among these new therapies, some were deemed promising in phase II...

Aims The incidence and predictors of stroke in patients with heart failure and preserved ejection fraction (HF-PEF), but without atrial fibrillation (AF), are unknown. We described the incidence of stroke in HF-PEF patients with and without AF and predictors of stroke in those without AF. Methods and results We pooled data from the CHARM-Preserved and I-Preserve trials. Using Cox regression, ...

OBJECTIVES We sought to derive and validate a prediction model by using N-terminal pro-B-type natriuretic peptide (NT-proBNP) and clinical variables to improve the diagnosis of acute heart failure (AHF). BACKGROUND The optimal way of using natriuretic peptides to enhance the diagnosis of AHF remains uncertain. METHODS Physician estimates of probability of AHF in 500 patients treated in the ...

BACKGROUND Hospitalizations for heart failure are associated with a high post-discharge risk for mortality. Identification of modifiable predictors of post-discharge mortality during hospitalization may improve outcome. Sleep disordered breathing (SDB) is the most common co-morbidity in heart failure patients. DESIGN, SETTING, AND PARTICIPANTS Prospective cohort study of patients hospitalized...

AIMS To determine the prevalence of right ventricular (RV) dysfunction in patients with preserved left ventricular (LV) ejection fraction (EF) heart failure (HF) and to compare RV function between patients with preserved EF HF and those with reduced EF HF. METHODS AND RESULTS Hundred patients (72 +/- 14 years, 59% male) with HF were prospectively enrolled. Fifty-one had preserved EF HF (LVEF ...