Objective(s): Tanshinone IIA (T. IIA), one of the most pharmacologically active components extracted from Salviae miltiorrhiza, has anti-inflammatory and antioxidant features. The aim of the present study is to investigate the benefit of T. IIA on asthma using a murine model of asthma induced by ovalbumin (OVA). Materials and Methods: Male BALB/c mice were used in the present study. The mice we...

This review presents the evidence that chronic obstructive pulmonary disease (COPD) is associated with significant sinonasal symptoms, inflammation and airway obstruction. Upper airway symptoms in COPD cause impairment to quality of life. The severity of upper airway involvement relates to that present in the lower airway, suggesting that the nose may be used to model the lung in COPD. More imp...

This is a critical review of the paper “An Airway Tree-shape Model for Geodesic Airway Branch Labeling” written by Feragen et. al. [1]. This paper presents a method for airway branch labeling by computing geodesic deformations between mathematical airway tree-shape models. The authors claim that the labeling results are good taking the large variation in the training set into account. Even thou...

BACKGROUND Retinoid X receptors (RXRs) are members of the nuclear receptor (NR) superfamily that mediate signaling by 9-cis retinoic acid, a vitamin A (retinol) derivative. RXRs play key roles not only as homodimers but also as heterodimeric partners-e.g., retinoic acid receptors (RARs), vitamin D receptors (VDRs), liver X receptors (LXRs), and peroxisome proliferator-activated receptors (PPARs...

human airway is generally destructed by inhaled factors and is the barrier to the external environment and has a crucial role in protection of the internal homeostasis of the lung. sulfur mustard (sm) is a chemical warfare that capable of producing severe chemical injuries primarily in the lungs. trefoil factor family (tffs) plays major roles in epithelial repair and homeostasis, particularly i...

intubating a patient with panfacial fractures is always a challenge to the anesthesiologist as both the anesthesiologist and the surgeon are essentially competing for the same space. the anesthetic management of a 19-year-old boy who presented with multiple maxillofacial injuries, pneumocephalus, and cerebral edema sustained during a road traffic accident has been described. he was posted for o...

a comparison on dentofacial cephalometric measurements between two mouth breathing groups with anterior and posterior obstructions of nasal airway zaeim* - dr. m.r. baghersad** dr. m.h. toodeh * - assistant professor of oral orthodontics dept. - faculty of dentistry - yazd university of medical sciences. ** - dentist. background and aim: the goal of this study was to compare dentofacial cephalo...

asthma is a heterogeneous disease, in which asthmatic patients present with different clinical phenotypes, variable endotypes, and different response to asthma medicines. thus, we are faced with an asthma paradox; asthma is diagnosed subjectively by clinical history and treated with biologically active drugs. to solve this paradox, we need objective airway biomarkers to tailor the proper medica...