The question of monitoring patients taking anticonvulsants has been reviewed previously. During carbamazepine monotherapy, complete blood counts (CBC) and alanine transaminase (ALT) were measured at intervals in 23 children attending a Pediatric Neurology clinic during 1990 and 1991. The results were reviewed retrospectively. The mean age was 10.3 years (SD 3.7 yrs). Prior to starting carbamaze...

BACKGROUND/AIM Both free alpha-galactosylceramide (αGalCer) and αGalCer-loaded dendritic cells (DCG) activate invariant natural killer T (iNKT) cells to varying degrees, with αGalCer inducing liver injury. We sought to evaluate liver injury by these two pathways. MATERIALS AND METHODS Mice were injected with αGalCer or DCG followed by analysis of serum alanine transaminase (ALT) activity leve...

AIM Hyperinsulinemia and insulin resistance are commonly seen in patients with hirsutism and polycystic ovary syndrome (PCOS), and are associated with cardiovascular disease risk. However, it is not yet known whether insulin-like growth factor I (IGF-I) and alanine transaminase (ALT) produced by the liver play roles in hyperinsulinemia and subclinical atherosclerotic process in patients with PC...

The liver is one of the major target organs affected in sepsis that are usually accompanied with free radical formation. The use of minus charge for the prevention and cure of various radical related diseases is gaining wide importance in the medicinal field. Here, we investigate whether minus charge stimulation (MCS) inhibits nitric oxide (NO) production induced by lipopolysaccharide (LPS) in ...

I.O. OMOTOSHO*, E.N. MADUAGWU AND L.I. OKEKE1 Departments of Biochemistry and Surgery1, College of Medicine, University of Ibadan. Nigeria ___________________________________________________________________________________________________ The formation of urinary dimethylinitrosamine [DMN] in male patients with benign prostatic hyperplasia [BPH] associated with urinary Tract infection [UTI] was...

conclusions udca decreased the pruritus score, tba, and alt levels more effectively than same, reducing the rate of preterm delivery for icp. evidence acquisition a meta-analysis of all randomized controlled trials (rcts) comparing udca, same, and combination therapy was performed. we carried out a literature search using pubmed, embase, the cochrane register of controlled trials, and the scien...

Background: Nonalcoholic fatty liver disease is a common cause of chronic diseases in developed countries. Ultrasound imaging widely used evaluation disease. The alanine transaminase and aspartate are laboratory investigations diagnosing diseases. Methodology: A cross sectional study was conducted at the Rizgary Hawler teaching hospitals from March to 2021 April 2022 on sample one hundred fifty...

Background: Since the low concentration and short-time treatment with sodium nitroprusside (SNP), a nitric oxide (NO)–donor, cause no harm to rat bone marrow mesenchymal stem cells (MSCs), we studied the impact of SNP on MSCs differentiation. Methods: MSCs were treated with 100 and 1000 µM of SNP for 1 hour in every 48 hours and after 5, 10, 15, and 21 days in osteogenic media. The viability an...

To facilitate molecular analyses of a previously uncharacterized gene involved in alanine synthesis, attempts were made to clone the wild-type allele of this gene, alaA, with a mini-Mu plasmid element used for in vivo cloning. Seventy-six independent Ala+ plasmids were isolated and characterized. Physiological, enzymological, and restriction endonuclease analyses indicated that three different ...

objective: to evaluate the hepatoprotective properties of otostegia persica (o. persica) ethanol extract on carbon tetrachlo­­ride-induced liver damage in rats. materials and methods: fifty adult male wistar rats were randomly divided into five groups. group i served as normal control and was given only olive oil intraperitoneally (i.p.). group ii, iii, iv, and v were administered ccl4 mixed wi...