BACKGROUND & AIMS Heat shock protein 90 (hsp90) is an emerging therapeutic target in chronic liver diseases. Hsp90 plays an important role in liver immune cell activation; however its role in alcoholic liver disease (ALD) remains elusive. Here we hypothesize that hsp90 is crucial in alcohol induced steatosis and pro-inflammatory cytokine production. To test this hypothesis, we employed a pharma...

context non-alcoholic fatty liver disease (nafld) is a chronic liver disease, with 5-10% of liver having extra fat. increase in its prevalence in all age groups is linked with obesity and type ii diabetes. the treatment of nafld remains controversial. a growing body of evidence suggests a relation between overgrowth of gut microbiota with nafld and non-alcoholic steatohepatitis (nash). the obje...

Correspondence to: Dr G J Gores, Mayo Clinic College of Medicine, 200 First St SW, Rochester, Minnesota 55905, USA; gores.gregory@ mayo.edu _________________________ P rompt removal of unwanted cells, such as senescent, damaged, genetically mutated, or virus infected cells, is crucial for the maintenance of liver health. This process is naturally achieved through a highly regulated programmed f...

conclusions it seems that surrogate liver function tests and adipocytokine levels were correlated with the histologic findings of the liver. objectives the aim of the study was to evaluate the correlation between serum adipocytokines and the histologic findings of the liver in patients with non-alcoholic fatty liver disease (nafld). patients and methods this case-control study was performed on ...

INTRODUCTION Non-alcoholic fatty liver diseases range from simple steatosis to non-alcoholic steatohepatitis. The "two hits" hypothesis is widely accepted for its pathogenesis: the first hit is an increased fat flux to the liver, which predisposes our patient to a second hit where increasing free fatty acid oxidation into the mitochondria leads to oxidative stress, lipoperoxidation and a chain ...

BACKGROUND Cognitive dysfunction has been observed in a range of liver diseases including chronic hepatitis C virus, alcoholic liver disease, primary biliary cirrhosis and Wilson's disease. Such dysfunction may range from mild cognitive changes to overt hepatic encephalopathy, and represents a significant complication of liver disease that may negatively impact the patient's quality of life, an...

Correspondence to: Dr G J Gores, Mayo Clinic College of Medicine, 200 First St SW, Rochester, Minnesota 55905, USA; gores.gregory@ mayo.edu _________________________ P rompt removal of unwanted cells, such as senescent, damaged, genetically mutated, or virus infected cells, is crucial for the maintenance of liver health. This process is naturally achieved through a highly regulated programmed f...

Abstract Diffuse liver disease is multifactorial and may arise from metabolic, storage, vascular or neoplastic drug-related toxicities. Metabolic disease, in particular non-alcoholic fatty its sequela of cirrhosis, an increasing worldwide epidemic with decompensation the development malignancy a major concern. This chapter aims to summarize current radiologic techniques early detection chronic/...

In the last three decades prevalence of insulin related diseases has been growing worldwide with epidemic obesity, type 2 diabetes mellitus and non alcoholic fatty liver disease. In children such epidemics are particularly worrisome, since metabolic abnormalities track to the adulthood with significant implications for the health care system. Epidemiological studies support a close association ...