BACKGROUND Chronic stress contributes to the development of brain disorders, such as neurodegenerative and psychiatric diseases. Oxidative damage is well known as a causative factor for pathogenic process in brain tissues. The aim of this study is to evaluate the neuroprotective effect of a 30% ethanol extract of Aquilariae Lignum (ALE) in repeated stress-induced hippocampal oxidative injury. ...

MOTIVATION Researchers need general purpose methods for objectively evaluating the accuracy of single and metagenome assemblies and for automatically detecting any errors they may contain. Current methods do not fully meet this need because they require a reference, only consider one of the many aspects of assembly quality or lack statistical justification, and none are designed to evaluate met...

BACKGROUND A new treatment strategy is to target specific areas of the skeletal system that are prone to clinically significant osteoporotic fractures. We term this strategy as the "local treatment of osteoporosis". The study was performed to investigate the effect of alendronate-loaded calcium phosphate cement (CPC) as a novel drug delivery system for local treatment of osteoorosis. METHODS ...

There is growing evidence that nerve growth factor (NGF) may function as a mediator of persistent pain states. We have identified a novel nonpeptidic molecule, ALE-0540, that inhibits the binding of NGF to tyrosine kinase (Trk) A or both p75 and TrkA (IC50 5.88 +/- 1. 87 microM, 3.72 +/- 1.3 microM, respectively), as well as signal transduction and biological responses mediated by TrkA receptor...

Both the heart sound and lung sound are produced within the almost same region of the human body. Heart sound makes severe interference while hearing the lung sound for the diagnosis purpose. So the separation of these sounds is very important for a accurate diagnosis. A special Advanced Line Enhancer (ALE), employing the strength of Singular Spectrum Analysis (SSA) is used in this paper. The S...

Mobile (smart)phones prevail in our daily life activities, and in our research we aim for it to provide pervasive services for wellness. Therefore, we assess the phone’s feasibility to unobtrusively, continuously and in real-time track its user’s physical activity and the resulting energy expenditure (EE). Activity Level Estimator (ALE) is an Android OS application developed for that purpose. W...

We identify a quiver variety of an affine type with a framed moduli space of torsion free sheaves on an ALE space, a fiber of a simultaneous resolution of the semi-universal deformation of C/Γ. This result is an analog of a similar identification for a framed moduli space of anti-self-dual connections on an ALE space, given by Kronheimer and the author. It simultaneously generalizes the descrip...