Objective(s): Pseudomonas aeruginosais a Gram-negative and aerobic rod bacterium that displays mucoid and non-mucoid phenotype. Mucoid strains secrete alginate, which is the main agent of biofilms in chronic P. aeruginosa infections, show high resistance to antibiotics; consequently, the biological disruption of mucoid P. aeruginosa biofilms is an attractive area of study for researchers. Algin...

Collagen, the main protein of body, is extracted in different forms and used as reservoir for drug delivery. The aim this work was to obtain adrug delivery systems based on collagen-dextran matrices cross-linked with glutaraldehyde support flufenamic acid and/or microcapsules drug. encapsulated polymeric consisting gelatin, alginate sodium carboxymethyl cellulose. morphology determined by water...

Biopolymers represent a great resource for the development and utilization of new functional materials due to their particular advantages such as biocompatibility, biodegradability non-toxicity. “Intelligent gels” sensitive different stimuli (temperature, pH, ionic strength) have applications in many industries (e.g., pharmacy, biomedicine, food). This review summarizes research efforts present...

pseudomonas aeruginosa is an opportunistic pathogen that causes a variety of infections in compromised patients. the ability of pseudomonas aeruginosa to produce chronic infection is based in part on its ability to biosynthesis of biofilm, and alginate is the major polysaccharide in the synthesized biofilm. so alginate degradation is very essential in the dispersion of pseudomonas aeruginosa bi...

The concept of biphasic or multi-layered compound scaffolds has been explored within numerous studies in the context of cartilage and osteochondral regeneration. To date, no system has been identified that stands out in terms of superior chondrogenesis, osteogenesis or the formation of a zone of calcified cartilage (ZCC). Herein we present a 3D plotted scaffold, comprising an alginate and hydro...

<strong>ABSTRACT. </strong> Garlic Oil is widely used as a raw material for fragrances with volatile active compounds at room temperature. It easily affected by environmental changes and this problem can be solved microencapsulation using coacervation methods to protect compounds. was encapsulated gelatin sodium alginate coating materia glutaraldehyde the crosslinking agent. The pur...

In this study, pH sensitive microsphere polymeric drug carriers were produced by using biodegradable natural gelatin and sodium alginate polymers. Microspheres loaded with prepared Ganoderma lucidum extract that is a medicinal mushroom has the potential to be used in several diseases’ treatment. Extract release kinetics of microspheres examined spectrophotometric method an UV spectrometer. Buff...

The gastrointestinal track has different pH values at sections. Thus, it is not easy to carry a drug the colon for absorption. sensitive polymeric macrosphere carriers have important advantages such as being able be taken orally, targeting active ingredient desired area and dosing concentration long time in target area. In this contex sodium alginate-gelatin macrospheres were produced by disper...