Enzymes of the AlkB and CYP153 families catalyze the first step in the catabolism of medium-chain-length alkanes, selective oxidation of the alkane to the 1-alkanol, and enable their host organisms to utilize alkanes as carbon sources. Small, gaseous alkanes, however, are converted to alkanols by evolutionarily unrelated methane monooxygenases. Propane and butane can be oxidized by CYP enzymes ...

DNA and RNA have various methylation modifications or damage that are directly related to some human diseases physiological regulation. Most of these reversible can be dynamically repaired by demethylases. Over the past few decades, enzymes from ALKB TET families been shown ability demethylate nucleic acids, which involves intermediates in oxidative repair process. These accurately captured adv...

background: the contamination of ecosystem with petroleum and its derivatives is con­sidered as one of the most crucial environmental threat in iran. application of micro­organisms has been demonstrated as an appropriate and more practical alternative to clean-up petroleum hydrocarbons in the contaminated environments. objectives: the objectives of this study were isolating rhizosphere-inhabiti...

Three hydrocarbon-degrading psychrotrophic bacteria were isolated from petroleum-contaminated Arctic soils and characterized. Two of the strains, identified as Pseudomonas spp., degraded C5 to C12 n-alkanes, toluene, and naphthalene at both 5 and 25 degrees C and possessed both the alk catabolic pathway for alkane biodegradation and the nah catabolic pathway for polynuclear aromatic hydrocarbon...

AlkB homolog 1 (ALKBH1) is responsible for the biogenesis of 5-formylcytidine (f5C) on mitochondrial tRNAMet and essential protein synthesis. The brain, especially hippocampus, highly susceptible to dysfunction; hence, maintenance activity strongly required prevent disorders associated with hippocampal malfunction. To study role ALKBH1 in we generated dorsal telencephalon-specific Alkbh1 condit...