OBJECTIVE The schistosomicidal properties of garlic (Allium sativum) and onion (Allium cepa) powder were tested in vitro against Schistosoma mansoni miracidia, schistosomula, cercaria and adult worms. Results indicate their strong biocidal effects against all stages of the parasite and also show scavenging inhibitory effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide (NO). MATERI...

Several studies suggest that the constituents of garlic may inhibit experimentally induced carcinogenesis. To evaluate the chemopreventive properties of garlic in humans, the effects of chronic administration of an aged garlic extract on the disposition of acetaminophen and metabolites were studied. This commonly used drug was chosen because it forms a reactive electrophilic metabolite after ox...

The genus Allium comprises about 700 species. Several of them are important vegetables, spices and medicinal plants. The most important crop species are onion and shallot, Allium cepa L., garlic, Allium sativum L., leek, Allium ampeloprasum L. s.l., bunching onion, A. fistulosum L., chives, A. schoenoprasum L., Chinese chives, A. tuberosum Rottl. ex Spr., and rakkyo, A. chinense G. Don. Many ot...

BACKGROUND Hypercholesterolemia is associated with an increased risk of heart disease. In this study, we investigated the antihyperlipidemic effects of garlic (Allium sativum L.) in rat models of hypercholesterolemic. METHODS Wistar male rats were randomly divided into 4 diet groups with garlic supplementation. Male Wistar rats were fed by standard pellet diet (group I), standard diet supplem...

AIM To study the effects of combinations of fenugreek (Trigonella foenum-graecum L.), garlic (Allium sativum), and black pepper (Piper nigrum) powder supplementation on production traits of broiler chickens. MATERIALS AND METHODS A total of 288 commercial broiler chicks were randomly assigned to 1-9 groups with 4 replicates each. An experiment was conducted in broilers with different feed for...

The sulfurous acid ester, trans-sulfurous acid allyl ester 3-allylsulfanyl-allyl ester 8, along with two known thiosulfinates was isolated from the aqueous ethanol extract of garlic (Allium sativum). The chemical structure of 8 was determined on the basis of spectroscopic data including high resolution mass and two-dimensional NMR techniques. All of these compounds induced methemoglobin formati...

BACKGROUND Epidemiological and experimental carcinogenesis studies provide evidence that components of garlic (Allium sativum) have anticancer activity. Hepatocellular carcinoma is highly malignant and metastatic. Currently, there is no effective chemotherapy for patients with advanced Hepatocellular carcinoma leading to an urgent need to seek for novel therapeutic options. AIM To investigate...

BACKGROUND Garlic (Allium sativum) has been shown to have important benefits in individuals at high cardiovascular risk. The aim of the present study was to evaluate the effects of the administration of aged garlic extract (AGE) on the risk factors that constitute the cluster of metabolic syndrome (MS). METHODS AND DESIGN Double-blind, crossover, randomized, placebo-controlled clinical trial ...

Essential oils of sixteen Chinese medicinal plants were screened for fumigant toxicity against Bemisia tabaci. The essential oil of Allium sativum exhibited the strongest fumigant activity against B. tabaci with an LC50 value of 0.11 μg/l followed by the essential oils of Agastache rugosa (LC50 = 7.08 μg/l), Illicium verum (LC50 = 8.61 μg/l), Chenopodium ambrosioides (LC50 = 8.80 μg/l), and Syz...

Both the growth and respiration of Candida albicans are sensitive to extracts of Allium sativum and investigations into the anticandidal activities are now focussing on the purified constituents to determine the targets of inhibition. Of particular interest is allyl alcohol (AA), a metabolic product that accumulates after trituration of garlic cloves. Putative targets for AA were investigated b...