Determination of transuranic elements such as U, Pu, Np, Am and Cm in spent nuclear fuels is of importance for a fuel characterization, evaluation of a burnup credit, and burnup determination of spent nuclear fuels. Additionally, the exact amount of the actinide elements, as the major elements of a source term, of the spent nuclear fuels is also used for a code verification that predicts the am...

Amastigotes of the protozoan parasite Leishmania proliferate in phagolysosomes of macrophages. They abundantly express glycoinositol phospholipids (GIPLs), which are considered necessary for parasite survival by providing a shield at the surface against lysosomal hydrolases and by serving as receptors for the interaction with host cells. The structures of four GIPLs of L. mexicana amastigotes w...

About one-third of oestrogen receptor alpha-positive breast cancer patients treated with tamoxifen relapse. Here we identify the nuclear receptor retinoic acid receptor alpha as a marker of tamoxifen resistance. Using quantitative mass spectrometry-based proteomics, we show that retinoic acid receptor alpha protein networks and levels differ in a tamoxifen-sensitive (MCF7) and a tamoxifen-resis...

In epithelial cells, alpha-, beta-, and gamma-catenin are involved in linking the peripheral microfilament belt to the transmembrane protein E-cadherin. alpha-Catenin exhibits sequence homologies over three regions to vinculin, another adherens junction protein. While vinculin is found in cell-matrix and cell-cell contacts, alpha-catenin is restricted to the latter. To elucidate, whether vincul...

background: some particular areas contain natural radionuclide at levels much higher than those usually present in earth's crust. the radiological impact of the use of zirconium ore in zirconium industry is due to internal exposure of the lung by alpha particles and external exposure of the body by the gamma rays. the result of gamma spectrometry measurement of the concentrations of the na...

This work aims to determine natural radionuclides (210Pb, 228,226Ra, 234,228Th and 40K) in NORM samples by well-type HPGe detectors because they are of vital importance studies on environmental samples. For this, a novel methodology has been developed, based obtaining general function for the full-energy peak efficiency (FEPE) versus sample apparent density composition, keeping height constant....

A simple, rapid liquid chromatography-tandem mass spectrometry method was developed to identify and quantitate in human urine the isoprostanes iPF(2 alpha)-III, 15-epi-iPF(2 alpha)-III, iPF(2 alpha)-VI, and 8,12-iso-iPF(2 alpha)-VI along with the prostaglandin PGF(2 alpha) and 2,3-dinor-iPF(2 alpha)-III, a metabolite of iPF(2 alpha)-III. Assay specificity, linearity, precision, and accuracy met...

BACKGROUND A role for myeloperoxidase (MPO) as a mediator of coronary artery disease and acute coronary syndromes has recently received considerable attention. Although active MPO and hypochlorite-modified proteins and peptides have been detected in human atherosclerotic lesions, detection of novel chlorinated oxidized lipid species with proatherogenic properties in vivo has not yet been report...

Encephalitozoon cuniculi is a microsporidian species which can induce subclinical to serious disease in mammals including rabbits, a definitive natural host. The pathophysiology of infection has not been comprehensively elucidated. In this exploratory study, we utilized two mass spectrometry approaches: first, the analysis of the humoral response by profiling the microsporidian antigens as reve...

This study reports the results of the gas phase oxidation of alpha-cypermethrin, a common insecticide, elucidating the decomposition pathways and formation of toxic species such as polychlorinated dibenzo-pdioxins and polychlorinated dibenzofurans (PCDD/F) and their precursors. Conditions investigated are similar to those encountered in post combustion and cooling-down zones of forest, agricult...