background: naltrexone, an opioid receptor antagonist shifts the immune response toward a th1 profile. in the current study, we evaluated the efficacy of the mixture of ntx and alum, as a new adjuvant, to enhance immune response and induce protection against leishmania major in a mouse model. methods : balb/c mice were immunized three times either autoclaved l. major promastigotes’ antigens alo...

Context: Vaccination is considered as the most cost effective method for the prevention of human diseases. For this prevention method, we need certain substances to increase or boost the antibody as well as cell-mediated immune response against various bacterial as well as viral pathogens. Until now, alum was considered as the safest adjuvant for human use, licensed by the United States Food an...

Introduction O f all medical innovations, vaccines have had by far the greatest impact in reducing the morbidity and mortality of infectious diseases. Although antigens have always been the lead products of the vaccine industry, over the last decade adjuvants have received far greater attention. The first vaccine adjuvants were developed in the 1920’s, when it was found that addition of irritan...

Intensification of the dairy industry in southern Idaho has led to the overapplication of manures and a buildup of soil phosphorus (P), which is a potential threat to water quality in the region. As the use of alum has been shown to reduce both soluble manure P and runoff P from alum-treated manures, the objective of this study was to determine if surface applications of alum to dairy manure an...

The use of Fenton's reagent (Fe2+/H2O2) and Fenton-like reagents containing transition metals of Cu(II), Zn(II), Co(II), and Mn(II) for an alum sludge conditioning to improve its dewaterability was investigated. The results obtained were compared with those obtained from conditioning the same alum sludge using cationic and anionic polymers. Experimental results show that Fenton's reagent was th...

BACKGROUND Naltrexone, an opioid receptor antagonist shifts the immune response toward a Th1 profile. In the current study, we evaluated the efficacy of the mixture of NTX and alum, as a new adjuvant, to enhance immune response and induce protection against Leishmania major in a mouse model. METHODS BALB/c mice were immunized three times either autoclaved L. major promastigotes' antigens alon...

Alum sludge refers to the by-product from the processing of drinking water in water treatment works. In this study, groups of batch experiments were designed to identify the characteristics of dewatered alum sludge for phosphorus adsorption. Air-dried alum sludge (moisture content 10.2%), which was collected from a water treatment works in Dublin, was subjected to artificial P-rich wastewater a...

A phase II clinical trial with glutamic acid decarboxylase (GAD) 65 formulated with aluminium hydroxide (GAD-alum) has shown efficacy in preserving residual insulin secretion in children and adolescents with recent-onset type 1 diabetes (T1D). We have performed a 4-year follow-up study of 59 of the original 70 patients to investigate long-term cellular and humoral immune responses after GAD-alu...

Research has shown that alum [Al(2)(SO(4))(3).14H(2)O] applications to poultry litter can greatly reduce phosphorus (P) runoff, as well as decrease ammonia (NH(3)) volatilization. However, the long-term effects of fertilizing with alum-treated litter are unknown. The objectives of this study were to evaluate the long-term effects of normal poultry litter, alum-treated litter, and ammonium nitra...