PURPOSE In a collaborative effort between the Missouri Department of Health, Area Agencies on Aging (AAA), Alzheimer Association, and academic researchers, we tested whether early dementia detection and comprehensive care consultations would improve health outcomes in care receivers (CRs) and their family caregivers (FCGs), therefore addressing an important public health concern. PARTICIPANTS...

We examined personality changes reported by a collateral source on the Blessed Dementia Scale in people who were nondemented when they entered a longitudinal study. Of the 108 participants examined here, 68 received a clinical diagnosis of dementia at some point after entry into the study. The other 40 participants died and came to autopsy with a clinical diagnosis of no dementia; however, 14 r...

In this paper, we tackle the problem of recognition of Alzheimer’s disease (AD) in structural MRI images using visual similarity. AD yields visible changes in the brain structures. We aim to recognize patient category such as AD, or prodromal stage of the AD called Mild Cognitive impairment (MCI), or normal control subject (NC).We use visual local descriptors and the bag of words approach on th...

BACKGROUND Knowledge of the evolution of cognitive deficits in Alzheimer disease is important for our understanding of disease progression. Previous reports, however, have either lacked detail or have not covered the presymptomatic stages. OBJECTIVE To delineate the onset and progression of clinical and neuropsychological abnormalities in familial Alzheimer disease. METHODS Nineteen subject...

Alzheimer disease (AD) is a progressive neurodegenerative disorder first affecting memory functions and then gradually affecting all cognitive functions with behavioral impairments. As the number of patients with AD has increased, early diagnosis has received more attention for both social and medical reasons. However, currently, accuracy in the early diagnosis of certain neurodegenerative dise...

In Alzheimer disease, neuronal degeneration and the presence of neurofibrillary tangles correlate with the severity of cognitive decline. Neurofibrillary tangles contain the antigenic profile of many cell cycle markers, reflecting a re-entry into the cell cycle by affected neurons. However, while such a cell cycle re-entry phenotype is an early and consistent feature of Alzheimer disease, the m...

Introduction Breast cancer is one of the most life-threatening conditions among women. Early detection of this disease is the only way to reduce the associated mortality rate. Mammography is a standard method for the early detection of breast cancer. Today, considering the importance of breast cancer detection, computer-aided detection techniques have been employed to increase the quality of ma...

myxomas, the most common primary cardiac tumors, are known as a source of cardiogenic emboli. the possibility of their early detection has made them of great importance for emergency medicines. detection of the disease is probable at early stages using echocardiography and associate complications such as syncope, cerebral embolic ischemic strokes, and sudden death. we report experience of a rar...