Treatment of a dinuclear Ru(II) amido complex [Cp*Ru(mu2-NHPh)]2 (Cp* = eta5-C5Me5) with small organic substrates including CO, tert-butyl isocyanide, a sulfur ylide Ph2S=CH2, and diphenylacetylene resulted in an unexpected disproportionation reaction of the bridging amido ligands to produce a free amine and a series of imido-bridged diruthenium complexes [(Cp*Ru)2(mu2-L)(mu2-NPh)] (L = CO, t-B...

The first examples of an amido-distibene, L(†)Sb[double bond, length as m-dash]SbL(†) (L(†) = -N(Ar(†))(SiPr(i)3), Ar(†) = C6H2{C(H)Ph2}2Pr(i)-2,6,4), and a boryl dibismuthene, {(DAB)B}Bi[double bond, length as m-dash]Bi{B(DAB)} (DAB = {(C6H3Pr(i)2-2,6)NCH}2, have been prepared by reaction of a lithium boryl complex, (THF)2LiB(DAB), with extremely bulky amido-group 15 dihalide precursor compoun...

Dodecacarbonyltriruthenium Ru3(CO)12 has been immobilized onto a biopolymer (chitosan) supported on SiO2 ([email protected]2) to give Ru?[email protected]2. [email protected]2 behaves as soft, recoverable and bulky ligand allowing the stabilization of released Ru active species preventing its irreversible reduction Ru0. Under these conditions very high activity (TOF= 1086 h?1; TON=2749) regiose...

L-Glutaminase is widely distributed in microorganisms including bacteria, yeast and fungi. The enzyme mainly catalyzes the hydrolysis of γ-amido bond of l-glutamine. In this report medium optimization was conducted through one -factor -at -a -time approach for the submerged production of L-Glutaminase by Streptomyces griseus using different additional carbon, nitrogen, amino acids, mineral salt...

Oxazoles are interesting from both a pharmacological and a chemical point of view. For example, they are known to interact with various proteins such as sodium-dependent excitatory amino acid transporters [1] or DNA repair protein OG-alkylguanine DNAalkyl-transferase [2], and furthermore, they display bacteriostatic [3] and antiinflammatory activity [4]. Additionally, oxazoles provide useful en...

All herpesviruses contain a ubiquitin (Ub)-specific cysteine protease domain embedded within their large tegument protein, based on homology with the corresponding sequences of UL36 from herpes simplex virus type 1 and M48 from murine cytomegalovirus. This type of activity has yet to be demonstrated for cells infected with a gammaherpesvirus. By activity-based profiling, we show that the large ...

Ferulic acid was used as a common drug for cardia-cerebrovascular disease and leukopenia, but the application of ferulic acid was inhibited by the poor absorption and stability. The improvement of these defects can be realized by modifying ferulic acid by amino acids, because the amido bond can increase the bioavailability and therapeutic effect of some drugs based on the peptide transporter sy...

An arginine aminopeptidase (EC 3.4.11.6) that exclusively hydrolyzes basic amino acids from the amino (N) termini of peptide substrates has been purified from Lactobacillus sakei. The purification procedure consisted of ammonium sulfate fractionation and three chromatographic steps, which included hydrophobic interaction, gel filtration, and anion-exchange chromatography. This procedure resulte...

Different optically active amido esters, mixed acid esters, amido acids, and diamides derived from trans-cyclopropane-1,2-dicarboxylic acid were prepared from the commercially available diethyl (±)-trans-cyclopropane-1,2-dicarboxylate. The key step was the Rhodococcus rhodochrous IFO 15564 catalyzed hydrolysis of the corresponding racemic amide. The amidase present in this microorganism showed ...

To generate a new specific recognition module for the enrichment and detection of ricin, galactose-functionalized silanized magnetic iron-oxide nanoparticles (Gal-SiMNPs) were assembled by amino-silanized MNPs (amino-SiMNPs) and a galactose linker. Amino-SiMNPs were produced by a coprecipitation method, and were coated with double layers of silica and aminosilane by hydrolysis of tetraethoxysil...