Abstract Mesoporous silica is an inorganic material that has high potential to be applied in various industrial fields, one of its applications the adsorption method. To maximize mesoporous silica, modification surface was carried out by adding amine compounds. The compound used as a modifier dimethylamine (DMA), using glycidoxypropyltrimethoxysilane (GPTMS) linking compound. column method uses...

Proteins are the workhorses of cells, acting as enzymes, structural elements, and signal transducers. The tremendous variability in proteins’ chemical and physical properties is achieved through the manner in which they are made—by the mixing and matching of a set of basic building blocks known as amino acids. Each amino acid consists of a carbon atom attached to an amine group, a carboxyl grou...

APRIL 2005 G ranulocyte colonystimulating factor (G-CSF) is a 19-kDa glycoprotein that stimulates proliferation, maturation, and functional activation of cells in the granulocyte lineage. Recombinant G-CSF is widely used to ameliorate neutropenia resulting from myelosuppressive chemotherapy and bone marrow transplantation as well as to mobilize peripheral blood progenitor cells for transplantat...

A de novo peptide that self-assembles into fibrillar structures and serves as a substrate for the cross-linking enzyme tissue transglutaminase was developed (Ac-QQKFQFQFEQQ-Am). Congo red staining, circular dichroism, and FTIR spectroscopy showed that this 11-amino acid peptide produced predominantly beta-sheet structures. TEM with negative staining and quick-freeze deep etch (QFDE) TEM showed ...

Chemical conjugation is commonly used to enhance the pharmacokinetics, biodistribution, and potency of protein therapeutics, but often leads to non-specific modification or loss of bioactivity. Here, we present a simple, versatile and widely applicable method that allows exquisite N-terminal specific modification of proteins. Combining reversible side-chain blocking and protease mediated cleava...

abstract: â in this study adiffusion based mathematical model was developed to compare the performance of amine-grafted adsorbents with that of 13x zeolite in a fixed-bed adsorption tower which is used to capture co2 from both humid and dry nitrogen stream under industrial conditions. the results show that the performance of amine-grafted adsorbent and 13x zeolite is almost the same in the dry ...

The synthesis and aqueous solution properties of a family of zwitterionic homo-, co-, and terpolymers derived from poly(2-vinyl-4,4-dimethylazlactone) (pVDMA) with tunable lower and upper critical solution temperatures (LCST and UCST) are presented. A RAFT-made pVDMA precursor was reacted with mixtures of zwitterionic sulfopropylbetaine (SPB) amine or sulfobutylbetaine (SBB) amine, tetrahydrofu...

Recent studies suggest that the second extracellular loop (o2 loop) of bovine rhodopsin and other class I G protein-coupled receptors (GPCRs) targeted by biogenic amine ligands folds deeply into the transmembrane receptor core where the binding of cis-retinal and biogenic amine ligands is known to occur. In the past, the potential role of the o2 loop in agonist-dependent activation of biogenic ...

Carbon nanotube (CNT) membranes allow the mimicking of natural ion channels for applications in drug delivery and chemical separation. Double-walled carbon nanotube membranes were simply functionalized with dye in a single step instead of the previous two-step functionalization. Non-faradic electrochemical impedance spectra indicated that the functionalized gatekeeper by single-step modificatio...

The development of DSM’s Hybrane hyperbranched poly(ester amides) is described. The monomer (1) for the hyperbranched polyester is obtained from the reaction of a cyclic anhydride with diisopropanol amine, yielding a tertiairy amide with one COOH and two OH groups. Polycondensation takes place via an oxazolinium intermediate in bulk at relatively mild conditions in the absence of catalyst. The ...