This study aimed to enhance γ-aminobutyric acid (GABA) in pigeon pea milk (CCM). The drink was prepared from germinated and fermented using the probiotic Lactiplantibacillus plantarum Dad-13. Various nutrients significantly increased GABA content milk, i.e., sucrose 3% (4409 mg/L), monosodium glutamate (MSG) 1% (59,562 whey 4% (5283 respectively. Glutamate decarboxylase (GAD)-encoding genes wer...

The effects of implantation of gamma-aminobutyric acid (GABA) and serotonin (5-HT) into the arcuate nucleus (ARC) on serum luteinizing hormone (LH) and prolactin (PRL) were examined in the conscious ovariectomized rat. Following implantation of 5-HT, but not GABA, serum PRL was significantly increased. While 5-HT did not affect pulsatile LH secretion, GABA significantly decreased the mean LH co...

Application of 4-(aminomethyl)cyclohexanecarboxylic acid (tranexamic acid; TAMCA) to the central nervous system (CNS) has been shown to result in hyperexcitability and convulsions. However, the mechanisms underlying this action are unknown. In the present study, we demonstrate that TAMCA binds to the gamma-aminobutyric acid (GABA) binding site of GABA(A) receptors in membranes from rat cerebral...

We study the conformation and reorientation dynamics of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) under neutral and acidic conditions using a combination of broadband dielectric relaxation spectroscopy and polarization-resolved femtosecond mid-infrared pump-probe spectroscopy. We find that both zwitterionic and cationic GABA adopt nearly linear conformations in aqueous solution...

Photochemical switches represent a powerful method for improving pharmacological therapies and controlling cellular physiology. Here we report the photoregulation of GABA(A) receptors (GABA(A)Rs) by a derivative of propofol (2,6-diisopropylphenol), a GABA(A)R allosteric modulator, which we have modified to contain photoisomerizable azobenzene. Using α(1)β(2)γ(2) GABA(A)Rs expressed in Xenopus l...

Abstract Gamma-aminobutyric acid (GABA) and glutamate are the primary neurotransmitters responsible for modulating excitatory inhibitory signalling within human brain. Dysfunctional GABAergic glutamatergic has been identified as a key factor in range of neuropsychiatric conditions; hence measurement modulation these neurometabolites is important improving our understanding conditions treatment ...

In plants, research on gamma-aminobutyric acid (GABA) has focused on its role as a metabolite, mainly in the context of responses to biotic and abiotic stresses. By contrast, studies of GABA in vertebrates have concentrated mainly on its role as a neurotransmitter and signaling molecule. Here, we discuss recent findings that point towards a possible role for GABA as a signaling molecule in plants.

γ-aminobutyric acid type B (GABA-B) receptor mediates the inhibitory transmission of γ-aminobutyric acid in the mammalian nervous system, being present in neurons and also in glial cells. Recently the presence of GABA-B has been demonstrated in Schwann cells (SC) suggesting its contribution in regulating the cell fate, maturation, and plasticity. Here, we further support the functional presence...

γ-Aminobutyric acid (GABA), and its positional isomers DL-α-aminobutyric acid (AABA) and DL-β-aminobutyric acid (BABA) have been analysed, in the solid state, using thermally stimulated current (TSC) spectroscopy. Secondary relaxations in these molecules have been detected for the first time. GABA displays two secondary relaxations at 77 ± 2 °C and 114 ± 2 °C, whilst AABA and BABA each display ...

Psychobiotics are defined as the organisms that can provide mental health benefit. The possible mechanism of psychobiotics is manipulation neurotransmitter production and by microbes. lactobacillus group has been reported for potential production, especially g-aminobutyric acid (GABA) which an important inhibitory neurotransmitter. Therefore, GABA be used relaxation applied in various psychiatr...