In a recent positron emission tomography (PET) study, we demonstrated the ability to measure amphetamine-induced dopamine (DA) release in the human cortex with the relatively high affinity dopamine D2/3 radioligand [(11)C]FLB 457. Herein we report on reproducibility and reliability of [(11)C]FLB 457 binding potential relative to non-displaceable uptake (BP(ND)) following an acute amphetamine ch...

Rationale: Lisdexamfetamine is a prodrug of D-amphetamine used for the treatment of attention-deficit/hyperactivity disorder (ADHD). Lisdexamfetamine is thought to have a prolonged pharmacokinetic profile compared with oral D-amphetamine, possibly associated with lower drug liking and a lower risk of oral misuse. However, differences in the pharmacokinetics and pharmacodynamics of lisdexamfetam...

Dopamine (DA) signaling at synapses is tightly coordinated through opposing mechanisms of vesicular fusion-mediated DA release and transporter-mediated DA clearance. Altered brain DA signaling is suspected to underlie multiple brain disorders, including schizophrenia, Parkinson's disease, bipolar disorder, and attention-deficit hyperactivity disorder (ADHD). We identified a pedigree containing ...

The development of amphetamine dependence largely depends on the effects of amphetamine in the brain reward systems. Ghrelin, an orexigenic peptide, activates the reward systems and is required for reward induced by alcohol, nicotine, cocaine and amphetamine in mice. Human genetic studies have shown that polymorphisms in the pre-proghrelin (GHRL) as well as GHS-R1A (GHSR) genes are associated w...

background increased prevalent use of methamphetamine is a global public challenge. information on drug use can be helpful in preventing high-risk behavior related to drug abuse. objectives this study aims to investigate the sexual function changes related to methamphetamine use in the male clients of public and private addiction treatment centers. patients and methods in this qualitative study...

Background: Drug abuse is a major issue and one of the main causes of health, psychological, and social problems. Studies have shown the effectiveness of narrative therapy in reducing psychological symptoms of addiction. The present study aimed to assess the effectiveness of group narrative therapy on depression, quality of life (QoL), and anxiety among people with amphetamine addiction in Kerm...

It was already found that Ang II AT₁ receptors are involved in the neuroadaptative changes induced by a single exposure to amphetamine, and such changes are related to the development of behavioral and neurochemical sensitization. The induction of the immediately early gene c-fos has been used to define brain activated areas by amphetamine. Our aim was to evaluate the participation of AT₁ recep...

background: work-related musculoskeletal disorders are the most important factors of absent from work, increased costs and human damages experienced by workers. the aim of this study was to determine the prevalence of work-related musculoskeletal disorders of nurses in al-zahra hospital and the effect of eight-week selected corrective exercises and ergonomic interventions on them. methods: nord...

background: adjustment disorder (ajd) is a transient mental health condition emerging after stressful life events. its diagnostic criteria have recently been under revision which led to the development of the adjustment disorder–new module 20 (adnm-20) as a self-report assessment. objective: to identify a threshold value for people at high risk for ajd. methods: as part of a randomized controll...

background: the use of methamphetamine and other drugs among young adults has been a theme of growing interest and concern on the part of researchers and health associations. this paper reports recent use of methamphetamine and its relation with some demographic variables among substance users in west of iran. method s: this cross-sectional study was carried out on 559 substance users of hamada...