BACKGROUND HIV-associated sensory neuropathy (HIV-SN) is a common and frequently painful complication of HIV infection and its treatment. However, few data exist describing the frequency, type and dosage of pain medications patients are receiving in the clinic setting to manage the painful symptoms of HIV-SN. OBJECTIVE To report on analgesic prescription for painful HIV-SN and factors influen...

interventions improve analgesic treatment of supracondylar fractures in a pediatric emergency department. BACKgRouND: Provision of appropriate and timely treatment for pain in the pediatric population has been challenging. Children with painful conditions commonly present to emergency departments (EDs), a setting in which it may be particularly difficult to consistently provide timely analgesic...

OBJECTIVES Cone snails are estimated to consist of up to 700 species. The venom of these snails has yielded a rich source of novel peptides. This study was aimed to study the analgesic effect of Persian Gulf Conus textile and its comparison with morphine in mouse model. MATERIALS AND METHODS Samples were collected in Larak Island. The venom ducts were Isolated and kept on ice then homogenized...

The noradrenalin and serotonin re-uptake inhibitor venlafaxine has an analgesic eŠect that is independent of its antidepressant activity; however, the mechanism of this eŠect remains to be elucidated. This study was performed to investigate the possible roles of the opioidergic system and nitric oxide (NO) pathway in the analgesic eŠect of venlafaxine. Eighty Wistar rats of both sexes were allo...

When meperidine (Demerol) was shown to possess marked analgesic properties (Eisleb and Schaumann, 1939) and thus became the first potent synthetic analgesic drug, the importance of the 1,4-substituted piperidine nucleus in providing analgesic activity became apparent. Many modifications of this basic chemical structure have been synthesized and studied pharmacologically in an attempt to achieve...

WHAT IS KNOWN AND OBJECTIVE Based on in vitro assays and select animal models, buprenorphine is commonly called a 'partial agonist'. An implication is that it should produce less analgesic effect in humans than so-called 'full agonists' such as morphine or fentanyl. However, buprenorphine has a multimechanistic pharmacology, and thus partial agonism at a specific receptor is not particularly re...

Conventional analgesics have limited efficacy in the management of neuropathic pain. An adjuvant analgesic is a drug that has a primary nonpain indication but which may be analgesic in certain circumstances, and many of these have established a role in the pharmacological treatment of neuropathic pain. The number needed to treat is an indirect statistical measure that can be used to compare rel...

The N-acylhydrazone (NAH) moiety is considered a privileged structure, being present in many compounds with diverse pharmacological activities. Among the activities attributed to NAH derivatives anti-inflammatory and analgesic ones are recurrent. As part of a research program aiming at the design of new analgesic and anti-inflammatory lead-candidates, a series of cyclohexyl-N-acylhydrazones 10-...

The aqueous fruit extract of Cucumis sativus L. was screened for free radical scavenging and analgesic activities. The extract was subjected to in vitro antioxidant studies at 250 and 500 μg/ml and analgesic study at the doses 250 and 500 mg/kg, respectively. The free radical scavenging was compared with ascorbic acid, BHA (Butylated hydroxyl anisole), whereas, the analgesic effect was compared...