In their article in the current issue of Clinical Chemistry, Farrell et al. (1 ) describe the latest in a number of studies (2, 3 ) highlighting the method-related variability in serum 25-hydroxyvitamin D (25-OHD) results. There is common agreement that 25-OHD is a “difficult” analyte. That quality is generally ascribed to its hydrophobic nature, its existence in several different molecular for...

We evaluated two multi-analyte analyzers, the NOVA Stat Profile 1 (SP 1) and the NOVA Stat Profile 5 (SP 5). The SP 1 measures pH, pCO2, pO2, sodium, potassium, ionized calcium, and hematocrit in heparinized whole blood; the SP 5 determines all these analytes, plus chloride (not evaluated because it was unavailable at the time this study was initiated) and glucose. Interassay precision for pH, ...

INTRODUCTION Nanoscaled aptamers (Aps), as short single-stranded DNA or RNA oligonucleotides, are able to bind to their specific targets with high affinity, upon which they are considered as powerful diagnostic and analytical sensing tools (the so-called "aptasensors"). Aptamers are selected from a random pool of oligonucleotides through a procedure known as "systematic evolution of ligands by ...

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In this work we present an electrochemical microfluidic platform for the detection of multiple analytes. The developed system allows the simultaneous readout of up to four different enzyme-linked assays even in various formats. The applicability was shown with the antibiotic detection of tetracycline in different concentrations by means of a DNA-based assay on a single chip. With a sample-to-re...

point of care (POC) in critical care areas such as the emergency department, neonatal and adult medical intensive care units, surgical intensive care units, and the operating room.2 The collection and analysis by portable or standard blood gas machines at or near the point of care minimizes the time needed to obtain and report laboratory values, which facilitates timely evaluation of results an...

surface-enhanced raman spectroscopy (sers) is a promising tool in the analytical science because it provides good selectivity and sensitivity without the labeling process required by fluorescence detection. this technique consists of locating the target analyte on nanometer range of roughed au-nanoparticles. the presence of the metal nanoparticles provides a tremendous enhancement to the result...

In this paper, a highly sensitive graphene-based multiple-layer (BK7/Au/PtSe2/Graphene) coated surface plasmon resonance (SPR) biosensor is proposed for the rapid detection of novel Coronavirus (COVID-19). The sensor was modeled on basis total internal reflection (TIR) technique real-time ligand-analyte immobilization in sensing region. refractive index (RI) region changed due to interaction di...

Surface-enhanced Raman spectroscopy (SERS) is a promising tool in the analytical science because it provides good selectivity and sensitivity without the labeling process required by fluorescence detection. This technique consists of locating the target analyte on nanometer range of roughed Au-nanoparticles. The presence of the metal nanoparticles provides a tremendous enhancement to the result...