1 Our understanding of anaphylaxis has greatly evolved since its fortuitous discovery by Portier and Richert, 1 but it is nowhere near enough. Uncertainty is more intensified in a lack of comprehensive understanding of predictors associated with severity or serious outcomes of anaphylaxis. In this sense, the article by Ye et al. 2 in this issue of the AAIR is greatly informative. They collected...

BACKGROUND The European Academy of Allergy and Clinical Immunology is in the process of developing its Guideline for Food Allergy and Anaphylaxis, and this systematic review is one of seven inter-linked evidence syntheses that are being undertaken in order to provide a state-of-the-art synopsis of the current evidence base in relation to epidemiology, prevention, diagnosis and clinical manageme...

Results 138 participants were included. 75% of participants recognised correctly signs of anaphylaxis before and 74% after the course. Regarding the correct position during anaphylaxis there were 77% correct answers before the course and 99% after. The rate of correct answers about adrenaline being the most important drug during the anaphylaxis increased from 72% before the course to 100% after...

We attempted to elicit active anaphylaxis to ovalbumin, or passive IgEor IgG 1 -dependent anaphylaxis, in mice lacking either the Fc e RI a chain or the FcR g chain common to Fc e RI and Fc g RI/III, or in mice lacking mast cells ( Kit W / Kit W-v mice), and compared the responses to those in the corresponding wild-type mice. We found that the FcR g chain is required for the death, as well as f...

Three reported episodes of anaphylaxis, where 1:1000 adrenaline was not immediately obtainable, triggered us to assess its availability on all adult wards. We found adrenaline was unavailable on 50% of audited wards. A questionnaire for doctors and nurses revealed lack of knowledge on both the management of anaphylaxis and location of emergency drugs. Given that anaphylaxis is a treatable but p...

PERIOPERATIVE anaphylaxis may be a life-threatening clinical condition and is typically a result of drugs or substances used for anesthesia or surgery. After anaphylaxis, allergologic assessment is essential to identify the offending agent and prevent recurrences, because no preemptive therapeutic strategies exist. This review seeks to (1) identify the clinical diagnostic pathway necessary to d...

Background Intraoperative anaphylaxis during sentinel lymph node biopsy is a well known phenomenon occurring with administration of patent blue and isosulfan blue dyes, with an incidence of 2.2% and 1.1%, respectively (1,2). Methylene blue has been reported as being a safer alternative with only a few case reports demonstrating anaphylaxis and large studies demonstrating no incidence of anaphyl...

A case of prehospital anaphylactic shock that presented atypically, without a known exposure, is discussed. Anaphylaxis is a potentially life-threatening allergic reaction that requires prompt recognition and aggressive treatment. While there is little diagnostic dilemma in the recognition and management of “classic” presentations of anaphylaxis there is likely a need for further education of p...

Idiopathic anaphylaxis is a rare life-threatening disorder with symptoms similar to other forms of anaphylaxis. There is lack of a robust evidence base underpinning the treatment of anaphylaxis and even less so for idiopathic anaphylaxis. Much of the evidence therefore comes from relatively small case series and expert opinion. Idiopathic anaphylaxis is a diagnosis of exclusion, requiring a tho...

I read with great interest the article by Armentia et al. recently published in Allergologia et Immunopathologia on food anaphylaxis in antiphospholipid syndrome (APS) and thrombosis. The authors suggested that seed lipoproteins might have a potential role in the APS and related thrombosis. I think that there are certain issues, which need clarification by the authors. The first issue in need o...