INTRODUCTION Anchorage control in patients with severe skeletal Class II malocclusion is a difficult problem in orthodontic treatment. In adults, treatment often requires premolar extractions and maximum anchorage. Recently, incisor retraction with miniscrew anchorage has become a new strategy for treating skeletal Class II patients. METHODS In this study, we compared treatment outcomes of pa...

Most human tumors harbor multiple genetic alterations, including dominant mutant oncogenes. It is often not clear which of these oncogenes are continuously required and which, when inactivated, may inhibit tumorigenesis. Recently, we developed a vector that mediates suppression of gene expression through RNA interference. Here, we use a retroviral version of this vector to specifically and stab...

OBJECTIVE The aim of this study was to identify the procedures adopted by Brazilian orthodontists in the following situations: extraction space closure, anchorage control in case of necessary anchorage for group A and frequency of skeletal anchorage use, especially in the upper jaw. METHODS A questionnaire was sent to the e-mail address of all dentists registered in the Brazilian Federal Coun...

BACKGROUND To evaluate the effectiveness of two minimally invasive surgical procedures in the acceleration of canine retraction: piezocision and laser-assisted flapless corticotomy (LAFC). METHODS Trial design: A single-centre randomized controlled trial with a compound design (two-arm parallel-group design and a split-mouth design for each arm). PARTICIPANTS 36 Class II division I patients...

We studied whether arsenic, nickel, and chromium compounds that are human carcinogens could induce transformation of cultured primary human diploid foreskin cells (HFC). All nickel compounds tested, PbCrO<, K2Cr2O7, CrO3, Na2HAsO4, NaAsO2, and jV-methyl-A/'-nitro/V-nitrosoguanidine (MNNG) caused significant (p = 0.001) dose-de pendent inductions of anchorage-independent colonies in HFC. kl l.. ...

The mammalian target of rapamycin (mTOR) is a nutrient and ATP sensor suggested to play an important role in tumorigenesis, particularly in the setting of PTEN loss or activated Akt/PKB. Of mTOR's two known effectors, eIF4E has been implicated in tumorigenesis, whereas the role of S6 kinase (S6K1) in transformation is less understood. To assess the contribution of S6K1 to the transformed phenot...